Photochemistry and electrochemistry of anticancer uracils (original) (raw)

The paper explores the photochemical and electrochemical properties of uracil and its derivatives, particularly focusing on 5-fluorouracil (5-FU) and its anticancer efficacy. The introduction highlights the various pharmaceuticals that uracil-related compounds are involved in, especially in cancer treatment, and reviews previous research techniques used to study these compounds. The study assesses the modifications made to 5-FU to enhance its medicinal properties through the use of derivatives and nanoparticles. It includes various experimental results illustrating the binding interactions between uracils and DNA across different pH levels, detailing both the binding constants and Gibbs free energy changes. The research emphasizes the significant role of electrochemical methods in understanding the behavior of these compounds and suggests future avenues for enhancing anticancer activity.