Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia (original) (raw)

Microglia play a critical role in the central nervous system's immune response, particularly during pathological conditions such as hypoxia and cellular damage. This study investigates how hypoxia affects purinergic P2X receptor-mediated inflammatory responses in brainstem microglia. Findings reveal that hypoxia attenuates the stimulatory effects of P2X receptor activation on inflammatory gene expression, indicating a potential mechanism through which hypoxic conditions may alter microglial responses and contribute to neuroinflammation in various CNS disorders.