Repetitive acute intermittent hypoxia downregulates inflammatory gene expression in the rat ventral cervical spinal cord (1091.7) (original) (raw)

The Faseb Journal, 2014

Abstract

ABSTRACT Intermittent hypoxia exerts pathologic and beneficial effects in the CNS, depending on the dose and duration. Whereas hundreds of hypoxic episodes per day mimic sleep apnea and promote neuroinflammation, low dose protocols, such as repetitive acute intermittent hypoxia (rAIH; 10 episodes of 10.5% O2 per day, 3 days/week for 4 weeks), upregulate growth/trophic factors and promote spinal motor plasticity. Because rAIH increases protein levels of key molecules associated with spinal respiratory motor plasticity, we hypothesized that the mRNAs for these and other molecules contributing to neuronal plasticity would be similarly increased. Nimblegen neuronal gene microarrays were used to profile transcript levels in the spinal ventral horn (C4-C6) of male Lewis rats exposed to normoxia or rAIH (n=3 arrays/condition). Surprisingly, there was little evidence of increased mRNA levels of pro-plasticity genes, and these results were confirmed with qRT-PCR for specific genes of interest. Instead, there were signifi

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