ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS (original) (raw)
Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells
Paul Lingor
Frontiers in cellular neuroscience, 2014
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ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells
Paul Lingor
Brain, 2007
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Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells
Gunnar P H Dietz, Paul Lingor
Molecular and Cellular Neuroscience, 2009
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Lehmann, M. et al. Inactivation of Rho signaling pathway promotes CNS axon regeneration. J. Neurosci. 19, 7537−7547
Ágnes Sebők
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
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Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration
Lisa McKerracher
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Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo
Adriana Di Polo
Journal of Neurochemistry, 2005
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ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases
Antonio Schmandke
The Neuroscientist, 2007
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Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates
John Steeves
Molecular and Cellular Neuroscience, 2003
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Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells
Kevin K Wang
Cellular & molecular biology letters, 2006
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Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord
Antonio Schmandke
Journal of Neuroscience, 2009
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AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo
vinicius ribas
Cell Death & Disease, 2021
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Direct Rho-associated kinase inhibiton induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells
Kevin K.W. Wang
Cellular & Molecular Biology Letters, 2006
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Axonal regeneration of cat retinal ganglion cells into the crushed optic nerve with a Rho/ROCK inhibitor
Yoshihito Tokita
Proceedings of Annual Meeting of the Physiological Society of Japan Proceedings of Annual Meeting of the Physiological Society of Japan, 2006
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Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve
Martin Schwab, Vincent Pernet
Cell death & disease, 2013
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
J. Lewcock, Trent Watkins
Proceedings of the National Academy of Sciences, 2013
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Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury
Satoshi Kuwabara
Journal of the Peripheral Nervous System, 2006
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ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury
Amy Davidow
Scientific Reports, 2021
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The Pivotal Role of RhoA GTPase in the Molecular Signaling of Axon Growth Inhibition after CNS Injury and Targeted Therapeutic Strategies
Enrique Torre
Cell Transplantation, 2007
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A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats
Yoshihito Tokita
Experimental Neurology, 2007
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Neurites regrowth of cortical neurons by GSK3β inhibition independently of Nogo receptor 1
Vanessa Gil
Journal of Neurochemistry, 2010
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Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma
Rose-Mary Boustany
ELECTROPHORESIS, 2012
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Neuroproteomics approach & neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration & neurotrauma
Stefania Mondello
…, 2012
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DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury
Kimberly Rhea Fernandes
Neurobiology of Disease, 2014
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AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo
vinicius ribas
Neurobiology of Disease, 2015
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Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
Chand Raza
Biomedicines
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DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris
Ty Lu
Proceedings of the National Academy of Sciences, 2014
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Rho kinase, a promising drug target for neurological disorders
Bernhard Klaus Mueller
Nature Reviews Drug Discovery, 2005
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Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration
Sara Blazejewski, Kazuhito Toyo-oka
Cellular and Molecular Life Sciences, 2020
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Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation
Larry Benowitz
Journal of Neuroscience, 2004
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Combined inhibition of apoptosis and necrosis promotes transient neuroprotection of retinal ganglion cells and partial-axon regeneration after optic nerve damage
Larry Benowitz
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