Review of Ethnomedicinal Uses and Pharmacology of Evolvulus alsinoides Linn (original) (raw)
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Review of Ethnomedicinal Uses and Pharmacology of< em> Evolvulus alsinoides Linn
Ethnobotanical Leaflets, 2008
Evolvulus alsinoides L. (Convolvulaceae) is used as nootropic or brain-tonic in traditional systems of medicine like Ayurveda and Unani. The plant is used by certain ethnic races across India, Africa and Philippines to cure fever, cough and cold, venereal diseases, azoospermia, adenitis, and depression. Pre-clinical (in vivo and vitro) investigations have demonstrated anti-amnesic, antistress (adaptogenic), antimicrobial and gastro protective activity.
ETHNOPHARMACOLOGICAL ACTIVITIES OF TRADITIONAL MEDICINAL PLANT: EVOLVULUS ALSINOIDES
Evolvulus alsinoides L. (E. alsinoides) an important medicinal plant is employed for different ailments in India traditionally and grows in the open and grassy places almost throughout India. The entire plant is considered astringent and useful for treating hemorrhages, also in other medical applications, including as an antipyretic, antiseptic, antioxidant, anticonvulsative, brain tonic, against asthma, bronchitis, scrofula, syphilis. This review summarizes the ethnopharmacological importance of Evolvulus alsinoides L. in traditional Indian medicine. KEYWORDS: This review summarizes the ethnopharmacological importance of Evolvulus alsinoides L. in traditional Indian medicine.
Therapeutic Potential of Evolvulus alsinoides
Journal of Drug Delivery and Therapeutics
Background: Evolvulusalsinoidesis a well-known herbal drug possessing various promising medicinal properties described by prominent ancient scholars and also numerous preclinical and clinical researches has been performed, thus attestingit’s ample of pharmacological actions. So, thorough review of classical as well as contemporary literature has been executed on Evolvulusalsinoides to validate the pharmacological actions mentioned. . Methods:For classical review,a comprehensive search of Unani literature is done and for latest research work on evolvulus, articles published in English language using PubMed, MEDLINE, and the Google scholar with search term including Sahnkpushpi, sankhaoli, Evolvulusalsinoides since 1991 to 2019 is done. Results: The search includescontemporary literature, ethnomedicinal sources and 35 research articles from 1992 to 2019 which further ascertains various pharmacological actions being mentioned in Unani literature including anti-inflammatory, a...
Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug
Chemical & …, 2007
Physiological adaptation during stressful conditions is defined as a biochemical change in an organism that results from exposure to certain environmental conditions or stressors and generates a more effective response to their survival. Long-term stress can induce a range of disorders like hypertension, coronary heart disease, 1) gastric ulcers, 2) immunosuppression, 3) metabolic disorders like diabetes, 4) reproductive dysfunction, 5) mental depression, memory loss and host of other diseases. 6) Due to the nonspecific nature of the stress pathogenesis, a drug having central and peripheral activity is needed to combat stressful conditions. Since ancient times therapeutic approach to combat stress has involved utilization of substances from natural origin. Pharmacological investigations have shown that the basic effect of Panax ginseng, Elutherococcus senticosus and Rhodiola rosea, is their ability to increase non-specific resistance of the organism to various untoward influences. 7) Initial studies on plants originating from folk medicine along with an exponential increase in knowledge regarding the interactions among components of the stress system have encouraged various investigators to evaluate the potential of plant derived anti-stress agents for usage in modern day medicine. Further enrichment of the study on plant derived adaptogens was enabled by the substantial work carried out on plants such as Ocimum sanctum, 8) Emblica officinalis, 9) Bacopa monniera, 10) Ginkgo biloba 11) and Withania somnifera. 12) In our continuing efforts to identify biologically active secondary metabolites, we have initiated our study on Evolvulus alsinoides to identify anti-stress agents.
Comparative pharmacognostical studies of two medicinally important Indian Evolvulus species
2015
The genus Evolvulus consists of small herbs or under shrubs distributed in the tropical and warm temperate regions of the world. Two species of this genus have been reported from India, viz. E. alsinoides L. and E. nummularius L. (Convolvulaceae). Both the species are traditionally being used as nerve tonic and for the treatment of skin diseases. The current study was carried out to provide comparative macro-microscopy, physicochemical parameters and TLC finger print profiles of aforesaid Indian Evolvulus species. The microscopy showed anisocytic stomata in E. alsinoides while diacytic and paracytic stomata in E. nummularius; presence of stellate trichomes, characteristic pith with spindle shaped deposition of calcium oxalate crystals and starch grains only in E. nummularius. Comparative TLC profile showed presence of some common as well as differentiating bands in methanolic extract of Evolvulus sp. However, the chemical markers, viz. ferulic acid, caffeic acid, β sitosterol and lu...
Evaluation of Anti-Inflammatory Activity of Evolvulus Alsinoides Plant Extracts
Journal of Pharmaceutical and Scientific Innovation, 2013
The aim of the study was to highlight the anti-inflammatory activity of Evolvulus alsinoids, it belongs to the family convolvulaceae and commonly known as shankhpushpi. The chloroform and Ethylacetae extracts of the plant has significant anti-inflammatory activity by both methods that is carrageenan and formalin induced paw oedema in rats at 200 and 400mg/kg body weight. In both models ethyl acetate extract was showed maximum activity.
Evolvulus alsinoides: A potential antihypertensive herb
2019
In spite of the fact that a variety of unfailing guidelines are existing for the management of hypertension, the problem of inadequate managing of this condition still continues. Several classes of existing antihypertensive drugs are associated with various side-effects. Since ancient times before the advent of anti-hypertensive drugs, this disease has been treated by the prominent classical scholars. Various herbal drugs are being used since ages for the treatment of hypertension and some of them are validated too. Evolvulus alsinoides is also one such herb used in classical literature since ages for various disorders like insanity, anxiety, nervous debility, epilepsy, melancholy, palpitation and many others. This review is to highlight the antihypertensive potential of Evolvulus alsinoides.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008
In recent years, great attention has been given to the search for natural compounds or extracts with the purpose of medical use. Evolvulus alsinoides L. (Convolvulaceae) is a plant used in traditional medicine of East Asia in many indications and has known nootropic and anti-inflammatory activity. However, the bioactive constituents have been described poorly in the literature. Four substances isolated from the ethanol extract of E. alsinoides by means of polyamide and Silica-gel chromatography are reported here. Their molecular structures were determined using NMR analyses. There were identified as scopoletin, umbelliferone, scopolin and 2-methyl-1,2,3,4-butanetetrol. The quantity of these substances was determined using HPLC-UV and GC-FID detection. Antioxidant activity of the isolated substances was measured by DPPH assay using the SIA method. Antioxidant activity and total phenolic content of the prepared fractions are also described. The prepared fractions and isolated substances did not exhibit any significant activity in DPPH test.
Antibacterial and antioxidant activity of methanol extract of evolvulus nummularius
Indian Journal of Pharmacology, 2009
of plants. In an attempt to screen plants growing in the forest of our campus for medicinal properties, we studied the antibacterial and antioxidant properties of methanol extract of E. nummularius. Materials and Methods Plant material E. nummularius (whole plant) were collected from the forest of Indian Institute of Technology campus, Guindy, Chennai for the study. The plant material was identified and authenticated by plant taxonomist, Dr. R.L.S. Sikarwar, Deendayal Research Institute, Chitrakoot. Preparation of methanol extract The 200 g plant material was washed and air-dried in the shade for 15 days. The dried plant material was ground to a fine powder in a blender. A measured quantity of 20 g of dried powder was soaked in 200 ml methanol in round bottom flask at room temperature for 24 h. The extract was filtered with Whatman No.1 filter paper. The filtrate was allowed to dry at room temperature until dry methanol extract was obtained. The weight of the dried extract was 0.63 g. The yield of extract Evolvulus nummularius (L). L known as Convolvulus nummularius belongs to the family Convolvulaceae (Morningglory). E. nummularius is a low growing species with creeping stem and rounded leaves. This herb is called by various names viz., Aakhukarni, Muusaakarni and Chhinipatra [1] and is widely distributed in India, Nepal, Bhutan, tropical America and Africa. In Indian traditional folk medicine, the whole plant is used as a medicine for hysteria, to cure burns, cuts, wounds and scropion stings. [2] In Nepal, the paste of the plant is used to treat scabies. [3] E. nummularius has been pharmacologically reported to possess antihelminthic activity, [4] wound healing activity, [5] poor sedative and anticonvulsant properties. [6] Three new compounds, 1-3 along with -sitosterol and its glucoside, stigmasterol, d-mannitol, ursolic acid and oleanolic acid have been isolated from the aerial parts of E. nummularius. [7] However, the antibacterial and antioxidant activities of the methanol extract of E. nummularius have not been reported. E. nummularius is a native species of Indian Institute of Technology Madras (IITM) campus. The forest of IITM has a rich biodiversity of flora and fauna. The forest has 298 species
The majority of adults around 65 years old suffer from Alzheimer's disease condition. It is a common type of dementia associated with memory loss and affects cognitive impairments. Due to fewer side effects and easy availability, the whole world is concerned about herbal products. Evolvulus alsinoides is one of the valuable herbal used to treat mental disorders in Ayurveda. The aim of this article is to find out the pharmacological effect of Evolvulus alsinoides and find out the effect of management on Alzheimer's disease condition. Objectives are to identify the phytochemicals and to identify the anti-inflammatory and antioxidant effects of this plant. Data were collected by using index journal articles in Google Scholar and pub med. Phytochemicals of This herb have a significant antioxidant effect and protect the nerves. Inhibiting effect of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, and IL-8. will reduce the formation of neurotoxins (β-Amyloid). Nootropic effects of Evolvulus alsinoides help to improve the cognitive function of the brain. Evolvulus alsinoides is the most effective drug to treat Alzheimer's disease condition.