Proton motive force drives the interaction of the inner membrane TolA and outer membrane Pal proteins in Escherichia coli (original) (raw)

Abstract

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The study investigates the interaction between the inner membrane protein TolA and the outer membrane protein Pal in Escherichia coli, emphasizing the role of the proton motive force (PMF) in facilitating this interaction. Various E. coli strains with mutations in the tol and pal genes exhibit enhanced sensitivity to drugs and detergents, linked to their outer membrane integrity and vesicle formation. Experimental data highlight that the TolA protein interacts with Pal, suggesting a potential cooperative mechanism that influences the stability and functionality of the bacterial cell envelope.

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