Neurotoxicity of Polychlorinated Biphenyls (PCBs) by Disturbance of Thyroid Hormone-Regulated Genes (original) (raw)

Ann N Y Acad Sci, 2005

Abstract

PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH-regulated genes in brain. To identify such genes, brain protein extracts of hypo- and hyperthyroid as well as PCB-treated embryos were compared by fluorescent 2D-DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo- or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur.

Veerle Darras hasn't uploaded this paper.

Let Veerle know you want this paper to be uploaded.

Ask for this paper to be uploaded.