Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indications at a tertiary care hospital (original) (raw)
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Journal of Evolution of Medical and Dental Sciences, 2015
To determine the pattern of NON STEROIDAL ANTI INFLAMMATORY DRUGS prescribing for arthritic and non-arthritic conditions in orthopedic outpatient department. METHODOLOGY: 100 prescription duplicate collected and analyzed prospectively for the pattern of NSAID prescription for arthritic and non-arthritic conditions; the drug formulation, route, frequency, duration of admission and concomitant medications results. NSAID were prescribed for nontraumatic musculo skeletal 35% pain, 25% post traumatic pain, 20% osteoarthritis, 10% postoperative pain, 3% ankylosing spondylitis, 6% degenerative disease of spine, 1% neuralgia. The NSAIDs commonly prescribed were Aceclofenac 45%, Etodolac 20%, Diclofenac 24%, and Ibuprofen 11%. Fixed dose combination of NSAIDs with adjuvante was prescribed in. The adjuvants, included are paracetamol 55.6%, serratopeptidase 32.8%, chlorzoxazone 9.1%, Thiocolchichoside 2.5%. oral formulations of NSAIDs were prescribed in all patients, supplemented by Topical formulations as gel/cream in 15% of subjects. The dosing frequency was BID (65%), OD (25%), TID (2%), SOS (8%). Duration of administration ranged from 5-15 days.other classes of drugs used concomitantly were proton pump inhibitors, calcium supplements, Multivitamins, Anti microbials, Immuno suppressants, and Glucosamine. CONCLUSION: NSAIDs were prescribed empirically for various arthritic and Nonarthritic conditions, frequently as fixed dose combinations [FDC]s with various adjuvants as per the standard guide lines. However patient information was inadequate in most of the prescriptions. Proper patient Assessment deemed necessary for individualizing NSAIDs.
Journal of Dhaka Medical College
Context: Non-steroidal anti-inflammatory drugs (NSAIDs) are most commonly used drugs for years for management of pain and inflammation with good efficacy. NSAIDs are increasingly used for variety of indications like rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP) etc. Prescribing patterns need to be evaluated periodically to increase the therapeutic efficacy, decrease adverse effects and provide feedback to prescribers. A prospective observational study was conducted among patients attending the Out Patient Department (OPD) of Orthopedic and received prescription for NSAIDs in the Mymensingh Medical College Hospital (MMCH) and Community Based Medical College Hospital (CBMCH) in Mymensingh. Material and Methods: The study was carried out on 300 (three hundreds) prescriptions for NSAIDs from orthopedic Out Patient Department (OPD) of Mymensingh Medical College Hospital (MMCH) and Community Based Medical College Hospital (CBMCH). A prospective observational study wa...
Prescribing Pattern of NSAIDs in Orthopedic Department of Dhaka Medical College Hospital
Journal of Dhaka Medical College
Context : Drug therapy is the most commonly used method in disease treatment in general practice. The pattern of drug prescription are often inappropriate and need for registration of these patterns is essentian in an effort to improve prescribing standard. Nonsteroidal antiinflammatory drugs (NSAIDs) are a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reliefing) effects, and, in higher doses, anti-inflammatory effects. Non steroidal anti inflammatory drugs are the most common drugs prescribed in the world over specially in the orthopedic department. The study of prescribing pattern of NSAIDs in the orthopedic department was conducted to monitor, evaluate and if necessary suggest modification in the prescribing behavior of the medical practitioner to make it rational and cost effective.
International Journal of Basic and Clinical Pharmacology, 2016
Background: WHO estimates that more than half of all medicines are prescribed, dispensed or sold inappropriately. Nonsteroidal anti-inflammatory drugs are a group of drugs that are commonly prescribed for the treatment of fever associated with pain and inflammation. The objective was to assess the prescribing pattern of NSAIDs in fever patients. Along with this, we looked at the clinical indications for prescribing and the pattern of prescribing with respect to use of generic or trade names. Methods: This observational study was conducted in a tertiary care teaching hospital in Malappuram district of Kerala, India by extracting data of inpatients retrospectively from medical records for a six-month period. The reported prevalence of NSAID use in previous study was 20%, with a relative precision of 18% the sample size required was 500. The data was analyzed and expressed as absolute numbers and/or percentages. Results: Out of these 500 patients, Dengue fever was the most common diagnosis (86.6%) followed by Typhoid (2.8%) and Leptospirosis (2.4%). Among these, 392 (78.4%) received any of the NSAIDs. The most commonly prescribed drug was Paracetamol (77.04%). Among to the prescriptions, 91.7% were prescribed with generic names. As concomitant medications, antibiotics were prescribed at 21.2% cases, gastro protective agents were prescribed to 24.23% and vitamins were prescribed in 72.6% cases. Conclusions: This study has shown that the prescribing, usage and preferences of NSAIDs practiced rationally. No over use, under use or misuse of drugs was noticed.
A Prospective Study About Prescribing Trends and Usage of Nsaids Among Arthritis Patients
2018
Background: Pharmacists are the custodians of drugs thus their education, training, behaviors and experiences would affect the future drug use at community and hospital pharmacies. Arthritis is a common disease that causes substantial morbidity in most patients and premature mortality in many. Purpose: The purpose of the study is to investigate the disease condition, treatment practices and proper guidelines of the arthritis in hospitals (Government and Private). To overcome and proper management of the associated complications different medications may need to be used. Method: This study was done based on the survey of prescribed medication to find out the pattern and use of medication during arthritis. Prescriptions were collected from different private and government hospitals, Pakistan. Statistical analysis was done using Microsoft Excel. Results: After evaluation of the prescription it was seen that arthritis more prevalent in females and usually occur at age of above 30 years....
Prescription Pattern Analysis of Non-Steroidal Anti-Inflammatory Drugs in Tertiary Care Hospital
Asian Journal of Pharmaceutical and Clinical Research
Objective: The aim of the study was to analyze the prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and to identify the commonly used NSAIDs and their drug-related problems (DRPs). Methods: A prospective and cross-sectional study on prescription pattern analysis of NSAIDs was conducted for the period of 6 months. Results: Prescriptions of 150 patients containing at least one NSAIDs were analyzed. About 56% of the prescription were prescribed for males and 44% prescription were female. NSAIDs were more prescribed for below 60-year age group (47%) but were most frequently used by 61–70-year age group (21%). Subjects were regularly prescribed with acetaminophen (95%) and diclofenac (22%). Among all the prescriptions, (19%) of the prescriptions contained NSAIDs in the form of fixed dose combinations (FDCs). About 37% of prescriptions had other analgesic coprescribed along with NSAIDs amid which tramadol was in majority (22%). Prescription was also coprescribed with...
Asian Journal of Pharmaceutical and Clinical Research, 2019
Objective: The objective of the study is to analyze the prescription pattern of drugs for osteoarthritis (OA) in a north Indian medical college collaborated with a tertiary care hospital. Methods: An observational study was conducted on 300 patients diagnosed with OA in the department of orthopedics in collaboration with the department of pharmacology, and thus, prescription was collected as in a cross-sectional manner for 6 months and the same were analyzed in the Department of Orthopedics in tertiary care hospital collaborated with medical college. Results: The average age of patients participating in this present study was 56.46±7.4 years with affected age group of 46-60 years. 60 % of females were affected by osteoarthritis outnumbering male (40 %) patients in this present study. The most commonly involved joint was knee joint (87.33 %) in patients diagnosed with osteoarthritis followed by back (6.67 %) and hip joint (6%). The combination therapy (90 %) outweighed monotherapy (10 %) with preferred route of drug administration as oral route (90 %) followed by topical route (10 %). The average number of drugs prescribed for patients of osteoarthritis was 2.62±0.76. This present study concludes that NSAIDs (45.8%) were prescribed most commonly. However, the drug paracetamol was lesser prescribed and other drugs such as Diclofenac (27.22 %) and acetaminophen (34.44 %) most of all followed by Nimesulide (16.67 %), ibuprofen (13.33 %) and Rofecoxib/valdecoxib (8.33 %) were prescribed. Conclusion: This present study concludes that NSAIDs were most commonly prescribed as p-drugs while paracetamol was undermined prescribed.
2019
Background: Inappropriate prescribing has been recognized in several health facilities in developing countries that need to be assessed periodically to improve the therapeutic efficacy, reduce side effects and provide feedback to prescribers. The purpose of this study was to compare the prescribing pattern of NSAIDs in two hospitals of the orthopedic outpatient department located in the Kathmandu valley of Nepal. Method: A cross-sectional hospitalbased descriptive study of a month duration (August 2017) with a purposive sampling method was undertaken for the data collection. WHO drug use indicators were selected to evaluate prescription patterns. A total number of 205 patients were eligible from hospital M and hospital K (135 and 70), respectively. Results: Among 135 patients studied in HM, the diagnosed orthopedic cases were joint pain (28.1%), low back pain (16.3%), traumatic case (19.3%), spinal case (3.7%) and others (32.6%) whereas studied 70 patients in HK were diagnosed joint...
IP innovative publication pvt ltd, 2020
Abstract Introduction: Osteoarthritis (OA) is a major cause of chronic pain and lower extremity disability among the elderly due to its predilection for lower extremity joints such as the knee and hip. The treatment of pain and inflammation is an important area of therapeutics. Over the past two decades, non steroidal anti-inflammatory drugs (NSAIDs) have played a central role in these indications. NSAIDs constitute the largest single group of drugs used worldwide, constituting more than 20% of all drug prescriptions. In India over 400 formulations of NSAIDs are marketed, resulting in wide spread exposure of patients to this class of drugs and its adverse effects, For all these reasons, studies that evaluate the pattern, extent and frequency of NSAID prescriptions are valuable. Periodic evaluation of drug utilization studies provides the information for suitable modifications in the prescription of drugs in order to increase the therapeutic benefit and decrease the adverse effect associated with drug Materials and Methods: A prospective, observational study was conducted on newly diagnosed as well as old treated patients with osteoarthritis from orthopaedic outpatient department in a tertiary care teaching hospital. A total of 428 were enrolled after screened for the inclusion and exclusion criteria. Data was recorded in a specially designed proforma which include information regarding the demographic profile of the patients and about the pattern of drugs prescribed. Results: Four hundred and twenty-eight patients with the diagnosis of Osteoarthritis visited the orthopedic outpatient department during the period of six months in which the data was collected. Prescriptions of all 428 patients were analyzed Osteoarthritis was found to be more common in males (56.07%) compared to that of females (43.92%). Results also revealed that, OA was more prevalent in middle age group of 51-65 years (45.32%),with knee joint (66.58%) being most commonly effected, majority of patient were treated with Combination therapy (80.80%) over Monotherapy (19.19%). Most of patients were treated as first line with NSAIDS (79.75%) and Paracetamol (20.10%), was under prescribed. Aceclofenac (32.85%) was the most common NSAID used followed by Diclofenac sodium (25.49%). Gastroprotective agents were used in 12.28% along with Non-selective NSAIDS to prevent gastrointestinal adverse effects, out of which Ranitidine (53.47%) was most preferred, followed by Pantoprazole (16.66%), Various other drugs were also used as adjunct therapies that includes, Calcium and Vitamin D3, symptomatic slow acting drugs for OA (SYSADOA) which included diacerin and glucosamine sulfate as combination in (10.15%) of patients. Conclusions: Our study showed Osteoarthritis most common among males affecting knee joint in middle age group, Paracetamol and SYSADOA being under prescribed and NSAIDS are the most frequently used drugs in OA. National drug policy is needed to rationalize the drug use and bring awareness among the prescribing doctors
International Journal of Basic & Clinical Pharmacology
Background: Treatment of Osteoarthritis aims at reducing pain and improving mobility. NSAIDS are commonly prescribed for symptomatic relief despite well documented adverse effects. Paracetamol with its better safety profile is recommended as the initial analgesic of choice. Osteoarthritis has significant socio-economic impact on the patients and not many studies are available to reflect upon the prescription pattern of drugs in Osteoarthritis. Hence, this study was chosen to generate important feedback to the clinician. The objectives of the study were to study the prescribing pattern of drugs used in the treatment of Osteoarthritis in Tertiary care hospital.Methods: Prescription for 300 osteoarthritis patients collected cross-sectional for 6 months from orthopedic out-patient department were analyzed.Results: 60% of females were affected. Average age of study was 56.46+/- 7.4 years. Knee joint (87.33%) was most commonly affected joint. Average number of drugs prescribed was 2.62 +/...