Evaluation of Some Biological Activities of Albizia lebbeck Flowers (original) (raw)
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Evaluation of Some Biological Activities of Albizia lebbeck Flowers
Pharmacology & Pharmacy, 2013
Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.
Evaluation of Some Biological Activities of <i>Albizia lebbeck</i> Flowers
Pharmacology & Pharmacy, 2013
Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.
Journal of Ethnopharmacology, 2009
Aim of the study: Albizia lebbeck Benth. is used both in Indian traditional system and folk medicine to treat several inflammatory pathologies such as asthma, arthritis and burns. The aim of the present study was to evaluate the scientific basis of anti-inflammatory activity of different organic solvent extracts of Albizia lebbeck. Materials and methods: The anti-inflammatory activity of Albizia lebbeck was studied using the carrageenan, dextran, cotton pellet and Freund's complete adjuvant induced rat models. The extracts obtained using petroleum ether, chloroform and ethanol were administered at the concentrations of 100, 200 and 400 mg/kg body weight. Results: The petroleum ether and ethanol extracts at 400 mg/kg, showed maximum inhibition of inflammation induced by carrageenan (petroleum ether-48.6%; ethanol-59.57%), dextran (petroleum ether-45.99%; ethanol-52.93%), cotton pellet (petroleum ether-34.46%; ethanol-53.57%) and Freund's adjuvant (petroleum ether-64.97%; ethanol-68.57%). Conclusion: The marked inhibitory effect on paw edema shows that Albizia lebbeck possesses remarkable anti-inflammatory activity, supporting the folkloric usage of the plant to treat various inflammatory diseases.
Preliminary Phytochemical Studies on Flower of Albizia Saman
2017
Preliminary screening of phytochemicals is a valuable step in the finding of bioactive compounds present in medicinal plants. The Albizia saman extracts and its solvent fractionates were subjected to preliminary phytochemical screening using standard phytochemical tests. The aim of the present study was to investigate the presence of phytochemicals and to determine the total phenolic and flavonoid contents of the selected medicinal plant. Soxhlet apparatus was used for the organic solvent extraction. Solvents used were water, methanol, ethanol, acetone, ethyl acetate, chloroform and petroleum ether. These investigations revealed the presence of flavonoids, tannins, saponins, carbohydrates, terpenoids, phenols and glycosides in the flower of the plant extracts and its fractionates.
THE ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE EXTRACT OF ALBIZIA LEBBECK IN ANIMAL MODEL
2009
The present study was intended to examine the analgesic effect of the 70% methanol extract of Torenia concolor Lindley var. formosana Yamazaki (TC MeOH ) and betulin using models of acetic acid-induced writhing response and formalin test. In addition, we investigated the anti-inflammatory effect of TC MeOH and betulin using model of λ-carrageenan-induced paw edema. We observed the activities of antioxidant enzymes (SOD, GPx and GR) in the liver and the levels of malondialdehyde (MDA) and nitric oxide (NO) in the edema paw. The results showed that TC MeOH (1.0 and 2.0 g/kg) and betulin (30 and 90 mg/kg), significantly inhibited the acetic acid-induced writhing response. TC MeOH (2.0 g/kg) and betulin (30 and 90 mg/kg) significantly inhibited formalin-induced licking time during both the early and late phases. TC MeOH (0.5, 1.0 and 2.0 g/kg) and betulin (30 and 90 mg/kg) also significantly decreased the paw edema at the 4th hour after λ-carrageenan injection. Furthermore, TC MeOH and betulin treatment also significantly increased the activities of SOD, GR and GPx in the liver while decreasing the level of MDA in the edema paw. Finally, betulin (30 and 90 mg/kg) also caused considerable reduction of NO level in the edema paw. Taken together, the present results indicated that TC MeOH and betulin possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of TC MeOH and betulin may be related to decreasing
Journal of Traditional and Complementary Medicine, 2016
Albizzia lebbeck Benth. (Mimosaceae) is a medicinal tree used to treat several inflammatory ailments in the Indian traditional Ayurvedic system of medicine. The aim of the present study was to evaluate the possible anti-inflammatory activity of the aqueous (AE) and ethanolic (EE) extracts of the leaves of A. lebbeck to support the ethnopharmacological claims. The study was carried out using Wistar rats (100e150 g). The AE and EE were prepared using the Soxhlet extraction process. The anti-inflammatory activity of the AE and EE of the leaves of A. lebbeck were studied using carrageenan-induced paw edema and cotton pellet-induced granuloma models. The AE and EE of the leaves of A. lebbeck at doses of 50, 100, and 200 mg/kg p.o. (oral administration) showed a dose-dependent and significant (p < 0.05) inhibition of carrageenan-induced hind paw edema with maximum percentage inhibition (PI) values of 22.
PRELIMINARY PHYTOCHEMICAL SCREENING OF Albizia lebbeck STEM BARK
International Journal on Integrated Education
Preliminary screening of phytochemicals is a valuable step in the detection of the bioactive chemicals in plants which may lead to drug discovery and could also be used for the treatment of various ailments. The aim of this experiment was to examine a preliminary phytochemical screening of Albizia lebbeck stem bark. The solvent used for the analysis includes: methanol, petroleum ether and water. The result obtained revealed the presence of alkaloids, tannins, terpenoids, saponins, phenols, flavonoids, glycosides, steroids, carbohydrates and proteins in all the solvent used. This bioactive chemicals and nutrients have therapeutic value and have been reported to be cheap, safe, and effective with no side effects in the body of animals.
Pharmacognosy Journal, 2016
Background: Albiza lebbeck leaves have been well known for its ethnopharmacological prospects. Objective: The present study aims three extracts (aqueous, methanolic and hydromethanolic) at two dose levels by oral administration by using immunomodulatory models and in vitro cell lines in correlation to analytical studies. Methods: The extracts were subjected to Haemagglutination Antibody Titre and DTH Delayed-Type Hypersensitivity reaction based on acute toxicity results. Chromatographic studies were undertaken comprising of Fourier Transform Infrared Spectroscopy and High performance Thin layer Chromatography and screened for in-vitro cell lines such as MCF-7 and HCT 15 by Sulforhodamine B Assay Method. Results: No response was shown at 100 mg/kg. Significant immunomodulatory effect was noticed at 200 mg/kg with Haemagglutination Antibody Titre (554.66 ± 102.78, 597.33 ± 85.35, 426.66 ± 53.98) and DTH Delayed-Type Hypersensitivity reaction (0.225±0.01, 0.21 ± 0.01, 0.23 ± 0.01) which showed decrease in paw volume (after 48 h) in case of Sheep Red Blood Cells, (0.5×10 9) used as antigens. Total flavonoids content in the extracts were revealed by methods described by Singleton and Quettier. Flavonols such as rutin and quercetin were detected by Fourier Transform Infrared Spectroscopy based on determination of the functional groups and High Performance Thin layer Chromatography showed well resolved spots. The extracts were screened on in-vitro cell lines (MCF 7 and HCT 15) by using Sulforhodamine B Assay method were unsatisfactory results were obtained at final concentrations of 10 μg/ml, 20 μg/ml, 40 μg/ml, 80 μg/ml. Conclusion: Thus, present paper suggests that extracts has served as a promising immunomodulator for immune system disorders.
Hepatoprotective activity and phytochemical study of Albizia lebbeck flowers
Planta Medica, 2015
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.