The Destabilizing Effect of Ribonuclease on the Helical Dna Structure (original) (raw)

There has been considerable recent interest in the possible effects of proteins upon the biological properties of DNA; the role of histones in regulation of RNA synthesis has been discussed by a number of workers,1'2 while Monod and his colleagues3 have suggested that in inducible enzyme synthesis the regulatory substance acting upon DNA is a protein. All of these studies have been concerned with the ways in which protein may regulate the stability of the helical DNA structure, making the bases more or less accessible for their potential roles in DNA and RNA synthesis.