Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia (original) (raw)
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Veterinary Medicine International, 2020
Background. Gastrointestinal helminth parasite infection is a major influencing factor against profitability of working equines all over the world. Objectives. A study was conducted from October 2016 to May 2017 in and around Hosaena to determine the efficacy of benzimidazole (BZ) and avermectin (AVM) chemical groups against strongyle nematodes in working donkeys. Methods. A total of 230 donkeys from Hosaena, Soro, Anlemo, and Gombora were randomly allocated into 5 groups of 46 donkeys in each group. All groups, except group 1 (control), were treated with ivermectin 1%, ivertong 10%, fenbendazole, and Fenacure 750 mg, respectively. Fecal samples were collected perrectally before treatment (day 0) and after treatment (day 14), and an egg per gram (EPG) value of >200 was used as a cutoff for inclusion to assess the efficacy of anthelmintics. Results. Accordingly, the study revealed that AVM was effective against strongyle nematodes of donkeys with the mean fecal egg count reduction...
A combination of cross-sectional and experimental study was conducted from December 2014 to January 2015 with the objectives of determining the prevalence of gastrointestinal nematodes and evaluating the efficacy of commonly used anthelmintic drugs in different sheep breeds in Areka agricultural research center sheep breed improvement farm, Wolayita, Southern Ethiopia. Prevalence study was conducted on the total of 229 sheep on station, belonging to 3 different breeds and the fecal egg count reduction test (FECRT) was used to evaluate the efficacy of anthelmintics. For the anthelmintic efficacy trial, a total of 72 sheep; 24 sheep for each breed were selected based on their higher fecal egg count (FEC) (>150 eggs).The sheep were randomly assigned in to four groups for each breed. Anthelmintics tested were Albendazole, Tetramizole and Ivermectin for each group of sheep breed. From the total 229 different sheep examined, the overall prevalence of one or more gastrointestinal parasites was 86.6%. Individual breed prevalence was 90% for pure dorper, 92.9% for cross bred and 84.2% for local indigenous breed Predominant worm species were strongyle (71.9%), Trichuris (1.5%) and 26% of the positive specimens were harboring multiple worm species. Evaluation of the efficacy of anthelmintic by using FECRT revealed that Ivermectin and Albendazole did show resistance while Tetramizole was 100% effective against parasite treatment in all sheep breeds. Therefore the farm should practice strategic deworming system to reduce the problem of anthelmintic resistance and more controlled experimental trials that consider different season, agro ecology and using more sensitive methods like egg hatch and larval motility assay with varieties of anthelmintic brands to complement and support this finding.
Uganda Journal of Agricultural Sciences, 2013
A study was conducted to determine the efficacy of albendazole (ABZ) and ivermectin (IVM) against gastrointestinal nematodes (GIN) in naturally infected goats in the pastoral region of Karamoja, Uganda. Fifty four (54) small East African goats (female = 36, male = 18), of 4-6 months and from 18 flocks, were allocated to treatment groups (albendazole, ivermectin and untreated control), by a randomized complete block design. Each group included 18 goats and treatments were administered according to weight of each goat, with 5 Mg/Mg bw albendazole and 0.2Mg/Kg bw ivermectin. Fecal egg counts (FEC), expressed as eggs per gram and larval cultures were done on day zero before treatment and on day 13 post-treatment. Anthelmintic efficacy was determined by the Fecal Egg Count Reduction Test (FECRT). ABZ and IVM reduced FEC by 81.03 and 96.55%, respectively. The results indicated that nematode resistance was present in the ABZ group. Coproculture results following albendazole treatmen...