original ) (raw )Probing the Role of the Histidine 759 Ligand in Cobalamin-Dependent Methionine Synthase †
Matthew Liptak
Biochemistry, 2007
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Spectroscopic Study of the Cobalamin-Dependent Methionine Synthase in the Activation Conformation: Effects of the Y1139 Residue and S -Adenosylmethionine on the B 12 Cofactor
Matthew Liptak , Thomas Brunold
Journal of the American Chemical Society, 2008
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A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor
Markos Koutmos
Proceedings of the National Academy of Sciences, 2008
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Crystallization and preliminary X-ray diffraction studies of the cobalamin-binding domain of methionine synthase from Escherichia coli
Rowena Matthews
Journal of Molecular Biology, 1992
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Cobalamin-Dependent and Cobalamin-Independent Methionine Synthases: Are There Two Solutions to the Same Chemical Problem?
Rowena Matthews
Helvetica Chimica Acta, 2003
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Structure of full-length cobalamin-dependent methionine synthase and cofactor loading capturedin crystallo
Johnny Mendoza
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A protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli
Jeffrey Scholten
Bioorganic & Medicinal Chemistry, 1996
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Mutations in the B 12 -Binding Region of Methionine Synthase: How the Protein Controls Methylcobalamin Reactivity †
Jeffrey Scholten
Biochemistry, 1996
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Synergistic, Random Sequential Binding of Substrates in Cobalamin-Independent Methionine Synthase †
Rowena Matthews
Biochemistry, 2006
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Insights into the reactivation of cobalamin-dependent methionine synthase
Markos Koutmos
Proceedings of the National Academy of Sciences, 2009
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Cobalamin-dependent methionine synthase from Escherichia coli B: electron paramagnetic resonance spectra of the inactive form and the active methylated form of the enzyme
Verna Frasca , Celia Goulding
Biochemistry, 1988
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Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes
Catherine Drennan
Current Opinion in Structural Biology, 1994
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Identification of the Zinc Ligands in Cobalamin-Independent Methionine Synthase (MetE) from Escherichia coli
James E Penner-Hahn
Biochemistry, 2001
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Cobalamin-Dependent Methionine Synthase Is a Modular Protein with Distinct Regions for Binding Homocysteine, Methyltetrahydrofolate, Cobalamin, and Adenosylmethionine †
Celia Goulding
Biochemistry, 1997
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Cobalamin-Independent Methionine Synthase from Escherichia coli : A Zinc Metalloenzyme †
James E Penner-Hahn
Biochemistry, 1996
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Crystal structures of cobalamin-independent methionine synthase (MetE) from Streptococcus mutans: A dynamic zinc-inversion model
Renaud Dumas
2011
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Crystal Structures of Cobalamin-independent Methionine Synthase Complexed with Zinc, Homocysteine, and Methyltetrahydrofolate
Renaud Dumas
Journal of Biological Chemistry, 2004
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Mechanism of reductive activation of cobalamin-dependent methionine synthase: an electron paramagnetic resonance spectroelectrochemical study
Scott Harder , Rowena Matthews , Stephen Ragsdale
Biochemistry, 1990
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Methionine Synthase Exists in Two Distinct Conformations That Differ in Reactivity toward Methyltetrahydrofolate, Adenosylmethionine, and Flavodoxin†
Rowena Matthews
Biochemistry, 1998
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Semi-empirical studies of cobalamins, corrin models, and cobaloximes. The nucleotide loop does not strain the corrin ring in cobalamins
Kurt Mikkelsen
Inorganica Chimica Acta, 2001
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Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryo-electron microscopy
Maxwell Watkins
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Elucidation of Substrate Specificity in the Cobalamin (Vitamin B12) Biosynthetic Methyltransferases: STRUCTURE AND FUNCTION OF THE C20 METHYLTRANSFERASE (CbiL) FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS
Peter Heathcote
Journal of Biological Chemistry, 2007
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Identification and Characterization of a Novel Vitamin B12 (Cobalamin) Biosynthetic Enzyme (CobZ) from Rhodobacter capsulatus, Containing Flavin, Heme, and Fe-S Cofactors
Kirsty McLean
Journal of Biological Chemistry, 2005
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MtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode
Tristan Wagner
Scientific Reports, 2016
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Intraprotein transmethylation via a CH3-Co(iii) species in myoglobin reconstituted with a cobalt corrinoid complex
Yoshio Hisaeda
Dalton transactions (Cambridge, England : 2003), 2015
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Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles
Richard Wheelhouse
FEBS Journal, 2007
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Defects in Auxiliary Redox Proteins Lead to Functional Methionine Synthase Deficiency
Lawrence Brody
Journal of Biological Chemistry, 1997
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Evolved Cobalamin-Independent Methionine Synthase (MetE) Improves the Acetate and Thermal Tolerance of Escherichia coli
Elena Mordukhova
Applied and Environmental Microbiology, 2013
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Changes in Protonation Associated with Substrate Binding and Cob(I)alamin Formation in Cobalamin-Dependent Methionine Synthase
Rowena Matthews
Biochemistry, 1997
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Reductive Cleavage Mechanism of Co−C Bond in Cobalamin-Dependent Methionine Synthase
Manoj Kumar
The Journal of Physical Chemistry B, 2010
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Zinc-Homocysteine binding in cobalamin-dependent methionine synthase and its role in the substrate activation: DFT, ONIOM, and QM/MM molecular dynamics studies
Safwat S A Abdel-azeim
Journal of Computational Chemistry, 2011
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The axial N-base has minor influence on Co–C bond cleavage in cobalamins
Ulf Ryde
Journal of Molecular Structure: THEOCHEM, 2002
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Characterization of the Zinc Sites in Cobalamin-Independent and Cobalamin-Dependent Methionine Synthase Using Zinc and Selenium X-ray Absorption Spectroscopy †
James E Penner-Hahn
Biochemistry, 2001
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Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model
Yoshio Hisaeda
Chemical communications (Cambridge, England), 2014
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Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12)
Rebekka Biedendieck
Proceedings of the National Academy of Sciences, 2013
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