Differentiation of Human Embryonic Stem Cells Encapsulated in Hydrogel Matrix Materials (original) (raw)

2000

Abstract

Prior work on many cell types, including stem cells, has definitively shown that mechanical stiffness of the neighboring material and the overall stress state influences cell behavior. There is also evidence that the topology (i.e. 2D vs 3D environment) impacts cell behavior. Our research involves controlling the differentiation of human embryonic stem cells (hESCs) through mechanical stimuli. We employ three-dimensional

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