Formulation of Orodispersible Tablets of Ondansetron HCl: Investigations Using Glycine-Chitosan Mixture as Superdisintegrant (original) (raw)

2009, Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan

The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron HCl using a direct compression method. A combination of glycine and chitosan was used as a disintegrating system and these tablets were compared for mechanical strength and disintegration time with those containing superdisintegrants. The Plackett-Burman screening design was used to screen the independent variables [concentration of glycine (X 1 ), concentration of chitosan (X 2 ), concentration of ondansetron HCl (X 3 ) and tablet crushing strength (X 4 )] which were found to actively in‰uence the dependent variables [disintegration time in the oral cavity (DT), wetting time (WT), and water absorption ratio (WAR)]. Further, a central composite design was used to formulate additional ODTs of ondansetron HCl for estimating response in the extended spherical domain. The regression analysis (performed using Statistica-7.0) of quad-raticˆt revealed that DT or WT and WAR were 99％ and 98％ correlated with active factors (X 1 , X 2 or X 3 ), respectively. The data showed that disintegration time of optimized ondansetron HCl ODTs was not signiˆcantly diŠerent (p＜ 0.05) from ODTs prepared using Croscarmellose sodium or Crospovidone.

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