Effects of metoclopramide and ranitidine on survival of flat template McFarlane skin flaps in a rat wound healing model (original) (raw)

This study investigates the effects of metoclopramide and ranitidine on the survival of flat template McFarlane skin flaps in a rat wound healing model. Chronic wounds pose a significant burden on healthcare systems, motivating the exploration of pharmacological strategies to enhance wound healing. The experiment involved 32 male Wistar rats divided into four groups, receiving either control treatment, metoclopramide, ranitidine, or a combination of both over a 3-week postoperative observation period. Key outcomes were observed regarding flap survival rates, quality of the wound bed, and histological evaluations, suggesting that the administration of these drugs may influence the healing process.