Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors (original) (raw)

New Approaches to the Treatment of Inflammatory Disorders Small Molecule inhibitors of p38 MAP Kinase

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Current Topics in Medicinal Chemistry, 2006

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6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

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Small Molecule p38 MAP Kinase Inhibitors for the Treatment of Inflammatory Diseases: Novel Structures and Developments During 2006- 2008

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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties

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Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

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Bioorganic & Medicinal Chemistry Letters, 2008

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Potent inhibitors of the MAP kinase p38

Ignatius Turchi

Bioorganic & Medicinal Chemistry Letters, 1998

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Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

Brian Hickory, Kevin D Jerome, Jeff Hitchcock

Bioorganic & Medicinal Chemistry Letters, 2011

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Novel triazolopyridylbenzamides as potent and selective p38α inhibitors

Laura Vidal

Bioorganic & Medicinal Chemistry Letters, 2012

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

Jeremy Green

ACS Medicinal Chemistry Letters, 2011

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SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

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Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors

Xuefei Tan

Bioorganic & Medicinal Chemistry Letters, 2010

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Mitogen-Activated Protein Kinase Inhibitor Anti-Inflammatory Effects of a p38

Jeffrey Madwed

2002

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Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Helen McBride, Ryan Wurz

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Identification of triazolopyridazinones as potent p38α inhibitors

Ryan Wurz

Bioorganic & Medicinal Chemistry Letters, 2012

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Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis

Peter Hiestand

Bioorganic & Medicinal Chemistry Letters, 2004

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Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition

John Braganza, Huey Shieh

Bioorganic & Medicinal Chemistry Letters, 2010

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Elevated GM-CSF and IL-1β levels compromise the ability of p38 MAPK inhibitors to modulate TNFα levels in the human monocytic/macrophage U937 cell line

David De Graaf

Molecular BioSystems, 2010

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Discovery of a new class of p38 kinase inhibitors

Ajay Bhargava

Bioorganic & Medicinal Chemistry Letters, 2000

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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Stephen de Laszlo

Biochemistry, 1999

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Design and synthesis of piperazine-indole p38α MAP kinase inhibitors with improved pharmacokinetic profiles

vinh tran

Bioorganic & Medicinal Chemistry Letters, 2010

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Design, synthesis and activity of a potent, selective series of N -aryl pyridinone inhibitors of p38 kinase

Win Naing

Bioorganic & Medicinal Chemistry Letters, 2011

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