Dendrocyin: An Isocucurbitacin with Novel Cyclic Side Chain from Dendrosicyos socotrana (original) (raw)
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Two new triterpenoida l glycos ides have been isolated from the secds of plant Dendrocalamus strict us and are characterised as jp, 2 1~, 28-t rih ydroxyolean-1 2-cn-28-0-{-~-o-arabi nopy ran osy l (1-)3) }-0-o-arab inopyranosyl(1-)3)-~-o-ara bin o ryran os id e I and 3p. 1 9a-. dih y droxYll~s-12-en-28-oa t e-3-0-p-o-arabin opyranos id e 2 on th e basis o f chemi cal and spectral evidence.
Four New Bibenzyl Derivatives from Dendrobium candidum
Chemical and Pharmaceutical Bulletin, 2009
Four new bibenzyl derivatives, namely, dendrocandins F-I (1-4), were isolated from the stems of Dendrobium candidum. Their structures were elucidated by the analysis of spectroscopic data. Dendrocandins F and G represent the fourth and fifth example of bisbibenzyl derivates with a dibenzopyran ring between two units, respectively. Dendrocandin H represents the first example of a bibenzyl derivative formed by a bibenzyl and a 1,4phenanthraquinone unit via a dibenzopyran ring. Compounds 1-4 were examined for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay.
Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves
Arkivoc
An investigation of the chemical composition of the root bark, seeds and leaves from the Australian plant, Denhamia obscura was carried out. Despite the traditional medicinal use of this plant by Indigenous communities in Australia and the comprehensive studies of other Denhamia species, the phytochemical profile of this plant has not been reported previously. Twelve known pentacyclic triterpenes, as well as seven abietane compounds were characterised. Two of the abietane compounds are new natural products, previously reported as synthetic compounds, obscurol and 13-methoxy-sempervir-6-ene. Friedelin was isolated from the root bark and leaves, with X-ray crystallography utilised to support its absolute configuration. The chemical compounds identified in this profile are consistent with other species now phylogenetically associated with the Denhamia genus.
a -Glucosidase Inhibitors from Dendrobium tortile
Records of Natural Products, 2016
From the whole plant of Dendrobium tortile, a new compound, namely 4-(2-hydroxypropyl)-2(5H)furanone, was isolated, together with six known compounds, which included trans-tetracosylferulate (2), cisdocosylferulate (3), p-hydroxybenzaldehyde (4), 3,4-dihydroxy-3,4-dimethoxybibenzyl (5), (2S)-eriodictyol (6) and dendrofalconerol A (7). The structures of these compounds were determined through analysis of 1-D and 2D NMR and HR-ESI-MS data. All of the isolates were evaluated for their -glucosidase inhibitory activity. Compound 7 showed strong -glucosidase inhibitory activity when compared with the positive control acarbose, whereas compounds 5 and 6 exhibited appreciable effects. An enzyme kinetic study revealed that compound 7 is a non-competitive inhibitor of -glucosidase. This is the first report of the chemical constituents with biological activity from D. tortile.
A New Bibenzyl-phenanthrene Derivative from Dendrobium signatum and its Cytotoxic Activity
Natural product communications, 2016
From the whole plant of Dendrobium signatum, a new bibenzyl-dihydrophenanthrene derivative, named dendrosignatol was isolated, together with the known compounds 3,4-dihydroxy-3,4'-dimethoxybibenzyl, dendrocandin B, dendrocandin I and dendrofalconerol A. The structure of the new compound was elucidated through analysis of its spectroscopic and mass spectrometric data. All of the isolates showed appreciable cytotoxic activity against three human cancer cell lines, including MDA-23 1, HepG2 and HT-29 cells.
Amotin and amoenin, two sesquiterpenes of the picrotoxane group from Dendrobium amoenum
Phytochemistry, 1978
Two new sesquiterpenes, amotin and amoenin, of the picrotoxane group were isolated from Den&&urn amoenum. The constitution of amoenin was evident from spectral investigations and by its conversion into or-dihydropicrotoxinin on oxidation with oxygen in the presence of platinum. The constitution of amotin was shown by its spectral properties and the conversion of aduncin into amotin by hydrogenolysis of its epoxide ring. That the configuration at C-4 in aduncin and amotin is R was supported by circular dichroism measurements on some derivatives of picrotoxinin and aduncin.
Frontiers in Nutrition, 2022
BackgroundMedicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach.MethodsA systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder.ResultsCurrent literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic β-cell dysfunction and insulin resi...
Dendrophen, a Novel Glycyrrhetyl Amino Acid from Dendronephthya hemprichi
Zeitschrift für Naturforschung B, 2011
Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.