Mycotic infections in diabetic foot ulcers in Emam Reza hospital, Mashhad, 2006-2008 (original) (raw)
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Incidence of mycotic infections in diabetic foot tissue
The objective of the study was to investigate the incidence of fungal pathogens in diabetic foot infections. A total of 74 Type II diabetic patients with non-healing diabetic foot infections were recruited for the study. Among the diabetic patients 65 % (48/74) had yeast and mold infections. Pathogenic yeasts were noted in 77 % of the patients of which Candida species was predominant (93 %). The major Candida species isolated were C. albicans (49 %), C. tropicalis (23 %), C. parapsilosis (18 %), C. guillermondi (5 %) and C. krusei (5 %). The other yeast species isolated were Trichosporon cutaneum and T. capitatum. Trichophyton spp. was the only dermatophytic fungus found. Molds were isolated from 38 % of the infected patients of which Aspergillus species predominated (72 %). The other molds isolated were Fusarium solani, Penicillium marneffei and Basidiobolus ranarum. The results of the study indicate the need for mycological evaluation of the non-healing diabetic foot tissues and a...
Study of fungal infections in diabetic foot Ulcer
innovative publication, 2017
Introduction: Diabetes is an important predisposing factor for fungal infections and causes significant morbidity and mortality. The study was carried out for detection of fungal infections in diabetic foot ulcers. Material and Methods: One year study was carried out on 80 patients. Samples were collected with the help of sterile swab. Direct microscopy by 10% KOH and for cultures samples were inoculated on two sets of SDA, one set incubated at room temperature and the other at 37 o C. Yeasts were identified by germ-tube tests, urease test, and sugar fermentation. Result: Out of 80 patients studied, 68.75% were male and 31.25% were female. Fungal culture positivity was seen in 17.5%.The predominant fungus isolated was C. albicans 42.85%, C. tropicalis 21.42%, C. glabrata 14.28%, T. mentagrophytes 7.14% T. rubrum 7.14% and A. fumigatus 7.14%. Conclusion: Fungal infections in diabetic patients if not detected and treated in time leads to the fatal complications such as foot amputation.
Fungal infection of the diabetic foot: two distinct syndromes
Diabetic Medicine, 2001
Aims Fungal infection of diabetic foot ulcers has not been described. We analysed the features of 17 patients with diabetic foot ulcers probably infected with fungi. Methods Seventeen patients were identi®ed with clinically infected foot ulcers, (i) which had failed to heal despite prolonged antibiotic therapy and intensive podiatric care, (ii) from which Candida spp. was isolated or hyphae T yeasts were visualized in material from ulcers or surrounding skin. Results Multiple ulcers arising simultaneously were present in 10 patients (59%), preceded by blistering in seven cases. Single ulcers with markedly ulcerated margins were present in seven (41%) patients and were preceded by blisters in two. All 17 cases had neuropathy and 15 (88%) had severe peripheral vascular disease. All ulcers responded to antifungal therapy. Conclusions Candida spp. is associated with two distinctive patterns of protracted ulceration in diabetic feet which improve following systemic antifungal therapy.
Fungal infection in foot diabetic patients
Journal of Basic Research in Medical Sciences, 2018
Diabetic patients are more susceptible to cutaneous fungal infections. Cutaneous lesions and Foot infections are a frequent complication of patients with diabetes mellitus, accounting for up to 20% of diabetes-related hospital admissions. Foot ulcers and other foot problems are a major cause of morbidity and mortality in people with Diabetes mellitus. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. More than 75% of diabetes mellitus (DM) patients are at risk for diabetic ulcers. About 15% of foot ulcers in diabetic patients lead to amputations. Although every 30 seconds one leg is amputated in the world due to DM, 80% of these cases are preventable. Poor controlled had significantly higher fungal infection in diabetic foot ulcers and require careful attention and management. The findings of various studies indicate that the prevalence of fungal infections in patients with diabetic foot ulcers is increasing and there are many drug resistance issues reported in this area, therefore more attention is important in diabetic centers about this neglected issue.
Study of Fungal Infection in Diabetic Foot Ulcer
International journal of scientific research, 2016
Background: The objective of this study is to determine the prevalence of fungal infection in diabetic foot ulcers and to study the factors influencing fungal positivity. Methods: A total of 100 diabetic foot ulcer patients admitted or who visited on outpatient basis to our hospital over a period of 1 year from May 2014 to April 2015. Fungal isolation from the ulcer was done by 10% KOH study, Gram stain, SDA culture and slide culture methods. The outcome of the disease was studied based on ulcer progression; wound healing & tissue loss/ amputation. Results: In present study polymicrobial flora in diabetic foot ulcer was seen (137 organisms in 100 subjects), predominantly with enterobacteriaceae and pseudomonas. Prevalence of coexisting fungal infection in the present study was 19% of which candida species was the commonest. Fungal infection was more commonly seen in long standing (4-5 months) non-healing ulcer on antibiotic therapy. Conclusion: The present study signifies the need o...
Fungal infections from the diabetic foot ulcers in AL-Samawah city
Al-Qadisiyah Journal Of Pure Science
A total of 150 samples from diabetic foot ulcers at many ages for both genders (86 male and 64 female) were collected from patients suffering from diabetic wounds infections who attending the Samawah Hospital of AL-Muthanna province during the period from June 2015 to May 2016. The fungal infections of diabetic foot were caused by Candida species. Candida albicans was the most common causative agent 46\103(44.66%) , followed by C. tropicalis, C. dublinensis, C. krusei, C.parapsilosis and C. guillermondi were 23 (22.33%), 15(14.56%), 9(8.73%), 6(5.82%) and 4(3.88%) respectively. The highest incidence was Aspergillus spp 23\47 (48.93%). The other molds isolated were Penicillium marneffei 14(29.78 %), Fusarium solani 8 (17.02 %), and Basidiobolus ranarum 2 (4.25 %).
Fungal Diabetic Foot Infections
The Egyptian Journal of Medical Microbiology, 2019
Background: Fungal infections play important role in pathogenesis of diabetic foot infections. Objective: to investigate the prevalence of fungi among patient with diabetic foot infections. Methodology: one hundred and twenty diabetic patients hospitalized due to foot infections were enlisted in this study. Deep tissue specimens from depth of the wound and nail samples were collected from the infected sites using the standard protocol. Laboratory identification of samples was done and pathogens were identified to the species level by morpho-physiological methods. Polymerase chain reaction was used to assess the presence of fungi in samples from infected sites. Results: Fungi were found in 51.7% of the patients. Candida albicans were the most predominant isolated organism (40.1%). Amphotericin B had 100% sensitivity against all Candida isolates. The most susceptible Candida species to fluconazole were C. dubliniensis and C. albicans. The most susceptible Candida species to voriconazole were C. dubliniensis. The most susceptible Candida species to itraconazole were C. dubliniensis. Of the study population, 70.0% had bacterial infection. The predominant isolates were Klebsiella spp. (32.7%). Mixed fungal and bacterial infections were seen in 20.3% of patients. Sensitivity of Pan fungal PCR was 97.4%, specificity was 92.4%. Conclusion: Fungal infections were more in patients with poor glycemic control. The role of antifungal agents in management of diabetic foot infections needs to be evaluated further.
East African Medical Journal, 2011
Objective: To isolate and identify fungal pathogens associated with dermatophytoses in diabetic patients and identify the spectrum of yeasts colonising diabetic foot ulcers at Kenyatta National Hospital. Design: A cross sectional Laboratory based study. Setting: The Kenyatta National Hospital diabetic clinic. Subjects: Sixty one patients with diabetic foot ulcers from August to November 2009. Results: The five most occurring pathogens were Biopolaris hawaiiensis (5.5%), Trichophyton schoenleinii (3.7%), Aspergillus niger (3.0%), Trichophyton rubrum (3.0%), Fusarium oxysporum (3.0%). Other moulds accounted forless than 3.0%. One suspected case (0.6%) of Penicilium marneffei was isolated although it couldnotbe ascertained due to its high containment requirement. Among the dermatophytes, the most occurring mould was Trichophyton schoenleinii (3.7%) while innon-dermatophyte was Biopolaris hawaiiensis (5.5%). Eight pathogenic yeasts were identified with C. parapsilosis (6.1%) being the most common followed by C. famata (3.0%). Fungal infestation was highest in callus formation (78.6%). Conclusion: Fungal aetiological agents are significant cause of diabetic woundinfection and may require antifungal intervention for successful management of diabetic foot ulcers.
Indian Journal of Endocrinology and Metabolism, 2014
Background: Superfi cial fungal foot infection (SFFI) in diabetic patients increases the risk of developing diabetic foot syndrome. Sixteen percent of urban population is suffering from diabetes in Sri Lanka. As the diabetes patients are more prone to get fungal foot infections, early intervention is advisable owing to the progressive nature of the infection. There is no data on the prevalence of SFFIs in diabetic patients in Sri Lanka. Objective: To determine the etiological agents causing SFFI in patients with type 2 diabetes. Materials and Methods: Three hundred eighty fi ve diabetic patients were included. Nail clippings and swabs were collected from the infected sites using the standard protocol. Laboratory identifi cation was done and pathogens were identifi ed to the species level by morpho physiological methods. Results: Clinically 295 patients showed SFFI, of which 255 (86%) were mycologically confi rmed for infection. Out of 236 direct microscopy (KOH) positives, 227 (96%) were culture positive. Two hundred and fi fty one patients (98%) with SFFI had diabetes for more than 10 years. Of the patients with SFFIs 92% had >100 mg/dl FBS and 81% had >140 mg/dl PPBS levels and 80% had both elevated FBS and PPBS. Non-dermatophyte fungal species were the commonest pathogens followed by yeast and dermatophytes. Conclusion: Aspergillus niger was the commonest pathogen followed by Candida albicans. SFFIs were seen signifi cantly with the increasing age, gender, duration of diabetes and with less controlled glycaemic level.
CANDIDA INFECTIONS OF DIABETIC FOOT ULCERS
2005
histopathologic diagnosis, microbiologic diagnosis SUMMARY The aims of the study were to determine the incidence of Candida infections of diabetic foot ulcers diagnosed by classic microbiologic and histopathologic methods, to study the influence of coexistent interdigital yeast colonization and dermatophytosis of one or both feet on the incidence of fungal ulcer infections, to propose the criteria for diagnosing fungal ulcer