Myonuclear domain in skeletal muscle fibers. A critical review (original) (raw)

This critical review explores the concept of the myonuclear domain (MND) in skeletal muscle fibers, highlighting its importance in understanding muscle growth and atrophy. The MND is defined as the volume of cytoplasm regulated by a single myonucleus, with implications for protein synthesis and overall muscle functionality. The review synthesizes findings regarding the relationship between myonuclear number and muscle fiber size, addressing controversies in the literature, and suggesting that changes in myonuclear number are crucial during hypertrophic and atrophic responses.