Effect of solids-polymer interactions on the properties of some aqueous-based tablet film coating formulations. II. Mechanical characteristics (original) (raw)
1984, International Journal of Pharmaceutics
The effect of interactions between film formers and dispersed solids on the permeation properties of some tablet film coats have been investigated. Two polymer systems were employed: hydroxypropyl methylcellulose (HMPC) and HPMC plasticized with polyethylene glycol (PEG) 400. Two types of titanium dioxide (one of which was surface-treated to increase its hydrophobocity) and two types of talc (differing in particle size) were the solids. The diffusion, solubility and permeability coefficients of the films were obtained from sorption-desorption experiments. Solids-polymer interactions and their effect on the permeation process are interpreted in terms of acid-base interactions and the presence or absence of water at the solid-polymer interface. It is also shown that the values of the critical pigment volume concentration (CPVC) based on permeability and diffusion data are not necessarily identical.
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