Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-α]-1,3,5-triazines as Human A2A Adenosine Receptor Antagonists with Improved Water Solubility (original) (raw)

Journal of Medicinal Chemistry, 2011

Abstract

The structure−activity relationship (SAR) of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives related to ZM241385 as antagonists of the A 2A adenosine receptor (AR) was explored through the synthesis of analogues substituted at the 5 position. The A 2A AR X-ray structure was used to ...

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