Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic β-Turn Templates and Validation as 3D Scaffolds (original) (raw)

The study focuses on the synthesis and analysis of cyclotetrapeptide mimetics, particularly exploring the structural enhancements provided by b-amino acids. By introducing a partially modified retro-inverso sequence and other modifications, the authors achieve more rigid scaffolds that exhibit b-turn structures. The validation of these compounds demonstrates their potential as effective 3D scaffolds for drug design, capable of yielding molecules with specific bioactive conformations, as exemplified by novel RGD peptidomimetics designed to interfere with integrin receptors.