Systemic lupus erythematosus in male: two case reports (original) (raw)
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BIRDEM Medical Journal, 2020
Rapidly progressive glomerulonephritis is one of the most dramatic and tragic presentations of lupus nephritis (LN) or renal manifestation of systemic lupus erythematosus (SLE). A 35-year-old Bangladeshi gentleman presented with worsening oedema, scanty, high colored, frothy urine and deteriorating renal function. He had puffy face, anaemia, oedema, normal jugular venous pressure (JVP), high blood pressure (150/90 mm Hg), ascites and bilateral pleural effusions. Diagnostic work-up confirmed SLE with class IV LN. His initial response to specific therapy showed improvement Birdem Med J 2020; 10(2): 137-138
SYSTEMIC LUPUS ERYTHEMATOSUS PRESENTING WITH LUPUS NEPHRITIS
Systemic lupus erythematosus often abbreviated as SLE or lupus, is a systemic autoimmune disease, in which the body's immune system mistakenly attacks healthy tissue. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation. We reported case of 36-year-old female Sudanese patient came to our center complaining of backache, generalized body ache and pain, easy fatiguability; joint pain and swelling; particularly knee joints; loin pain, oligouria, suprapubic pain and burning micturition.
Case Report on Systemic Lupus Erythematosus
Indian Journal of Forensic Medicine & Toxicology, 2020
Background: Systemic Lupus Erythematous (SLE) is a multi-system chronic but often episodic,autoimmune condition defined by widespread inflammation of connective tissues and immune complexmediated vasculitis as well as the involvement of Antinuclear Antibodies.Case Presentation: The 11 years old female patient who was apparently alright 2 months back admittedin “Acharya Vinoba Bhave Rural Hospital Sawangi (M), Wardha,” Maharashtra on date 22/02/2020 withthe chief complaint of high-grade fever on and off since 2 months and facial puffiness since 6 days, ascites,constipation and pain in joints. The patient started experiencing fever 02 months back which was highgrade and she took treatment on an OPD basis but there was no relief. After that she was admitted at GMCChandrapur for the complaint of cough, cold, fever and oral ulcer and symptomatic treatment was given andgot discharged after 12 days. Fever, facial puffiness, pain in knee joints. The patient had undergone variousinvestigatio...
Journal of Rheumatic Diseases and Treatment, 2015
Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous phenotypes. Although serosal inflammation is common in SLE, massive pleural ascites and large volume pleural effusions as presenting features are unusual. Unlike most cases of lupus serositis, patients with these large effusions tend to require aggressive management with high dose steroids and steroid-sparing agents [1]. Methods Two case reports of SLE presenting as serositis with large volume effusions are described. A literature review was performed using a Pubmed search (1964-2015) for all reported cases of large volume ascites or pleural effusions as the presenting features of new onset SLE. The following search terms were used: SLE/Lupus serositis, ascites, pleuritis, peritonitis, pleural effusion, peritoneal effusion. Only adult cases in the English language were reviewed. Case Reports Case 1 A 50-year-old immigrant from Central America, was admitted with rapidly increasing ascites. Medical problems included hypertension, chronic hepatitis C with cirrhosis and portal hypertension (treated with an 8 month course of PEG-IFN one year prior to admission), and end-stage renal disease (ESRD) status post cadaveric renal transplant 10 years prior but complicated by transplant rejection and new hemodialysis requirement over the last two years. On presentation, the patient was febrile with cervical lymphadenopathy, accompanied by massive non-tender ascites with hemodynamic compromise requiring serial large-volume paracentesis (Figure 1). The serum-ascites albumin gradient (SAAG) was < 1.1, which was inconsistent with portal hypertension ascites or possible nephrotic syndrome given the end stage renal disease. Ascitic fluid WBC counts ranged from 77-675/mm 3 with a lymphocytic predominance. Peritoneal fluid bacterial, fungal,
Kanem Journal of medical Sciences, 2021
Background: Lupus nephritis (LN) is an immune complex glomerulonephritis that complicates up to 40% of SLE patients. A kidney biopsy is required for diagnosis and staging of the disease. Case report: We report a cohort of five patients with LN from a tertiary health facility in northeastern Nigeria. The five patients were all women with age ranging from 26 to 55 years, and eGFR of between 6 to 154ml/minute. Four patients had normal kidney size and were biopsied whereas 1 patient had contracted kidney. Diffuse proliferative LN (Class IV) was seen in two patients while the other two patients had glomerular sclerosis (Class VI). Patients were given induction with methylprednisolone and mycophenolate mofetil (MMF). At one year follow up 2(40%) patients were in remission, 1(20%) was on maintenance hemodialysis and 2(40%) patients had died. Conclusion: Lupus nephritis is a common complication of SLE in northeastern Nigeria. Patients have features of advanced kidney disease at presentation. CASE SERIES to develop LN are of younger age, males and black, Hispanic or of Asian ethnicity. Studies have shown that 60% of black SLE patients develop LN, with 25-50% having LN as an initial manifestation 4 of SLE. The clinical presentation of LN is variable with most patients presenting with mild proteinuria and haematuria. Some patients will present with 'silent' LN (normal renal function and urinalysis), severe proteinuria (nephrotic syndrome), acute nephritic syndrome and/or acute kidney failure. Renal involvement in SLE is defined by persistent proteinuria (more than 0.5 g of protein per day, 3+ on dipstick or a urinary protein to creatinine ratio or 24h urinary protein excretion corresponding to 0.5 g daily) or the presence of cellular casts (either red blood cell, haemoglobin, granular, tubular or 5, 6 mixed) in urinary sediment. Definitive diagnosis of LN is by kidney biopsy in which, LN is categorized into various histological
CASE REPORT: PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND MANIFESTATIONS OF LUPUS NEPHRITIS (Atena Editora), 2023
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown etiology. It has a very varied clinical picture, which may involve skin, joint, vascular, renal, neurological and other systems. Renal involvement is prevalent and serious, requiring careful clinical management. Therefore, this article is a case report of a patient whose follow-up and treatment were carried out in the Nephrology department of Santa Casa de Misericórdia de Passos. Data were collected from the patient's medical records and literature. The patient's informed consent form was obtained. The evolution of a patient with SLE was described, from suspicion, diagnosis, treatment, correlating with data from the literature.
Fever of unknown origin in a male patient with systemic lupus erythematosus
Caspian Journal of Internal Medicine, 2017
Background: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disorder which is uncommon in men. It has a wide variety of clinical presentations. Case Report: We report a 21-year-old male presented with one month history of fever, loss of appetite, weight loss and reduced hair growth with an examination revealing an oral ulcer, cervical and axillary lymphadenopathy simulating hematological malignancy. Investigations showed pancytopenia, positive anti-nuclear factor and double-stranded DNA, high erythrocyte sedimentation rate with normal C-reactive protein levels and hypocomplementemia. The diagnosis of systemic lupus erythematosus was made and treatment with oral prednisolone conferred a dramatic clinical and biochemical improvement within one week. Conclusion: In the evaluation of fever of unknown origin, one should be guided by the presenting symptoms and signs of a patient and even though uncommon, SLE is a worthwhile diagnosis to investigate even in a male patient if the clinical picture is suggestive.