Comparing the effects of chlorhexidine and persica on alveolar bone healing following tooth extraction in rats, a randomised controlled trial (original) (raw)
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Dental Journal (Majalah Kedokteran Gigi)
Background: Inflammatory cells and fibroblasts have an essential role in the wound healing process. Persea americana Mill. seed categorises as a waste; it contains rich nutrients that can accelerate wound healing activity. Purpose: This study aims to determine the effect of Persea americana Mill. seed against inflammatory cells and fibroblast formation in tooth extraction socket healing. Methods: Ninety-six Sprague Dawley rats had their lower left molars removed. Forty-eight rats tested for inflammatory cells were divided into four groups: negative control group (IC1), positive control group (IC2), Persea americana Mill. seed extract concentrations of 50% (IE1) and 90% (IE2). Another 48 rats used for fibroblast were divided into three groups: the control group (FC1), Persea americana Mill. seed concentrations of 50% (FE1) and 90% (FE2). The gel was applied to the socket under general anaesthesia. Four rats from each group were decapitated for histopathological tissue preparations wi...
Healing of extraction wounds in an experimental model of rat
Acta stomatologica Naissi, 2011
uniVerzitet u niŠu, MediCinski Fakultet, klinika za stOMatOlOGiju Odeljenje Oralne hirurGije uniVersitY OF niŠ, MediCal FaCultY and CliniC OF stOMatOlOGY, dePartMent OF Orl surGerY ABSTRACT Uvod: Proces zarastanja rane nakon ekstrakcije zuba je sa velikom pažnjom istraživan kod nekoliko životinjskih vrsta pod normalnim i eksperimentalnim uslovima koji bi mogli ometati zarastanje. Hronologija zarastanja rane nakon ekstrakcije zuba -molara i inciziva se kod pacova odvija u nekoliko faza i ispitivana je histološkim, radiografskim, dezintrometrijskim, imunohistohemijskim i stereološkim(tačkasta volumetrija) metodama, kao i upotrebom mini kamere za određivanje volumenske frakcije histoloških komponenti Cilj rada: Na osnovu literature dostupne u elektronskim bazama podataka analizirati histolo-ške i radioloske rezultate o toku zarastanja normalne ekstrakcione rane pacova i ABSTRACT Introduction:
European Journal of Dentistry, 2022
Objective This study aimed to evaluate the effect of 0.2% chlorhexidine (CHX) gel on wound healing after tooth extraction. Materials and Methods A single blind, randomized controlled trial was performed recruiting 32 participants who underwent dental extractions. Patients were randomly allocated for CHX group or placebo group. The primary outcomes were wound closure measured with calipers and healings were assessed by Landry et al index after 7 days of topical application of allocated gels on extraction sites. Results The wound closures were greater in CHX group compared with placebo group and healing scores were correlated with the use of CHX gel (p-value
Histometric study of socket healing after tooth extraction in rats treated with diclofenac
Brazilian Dental Journal, 2002
The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.
Extraction wound healing in desalivated rats
Journal of Oral Pathology and Medicine, 1991
Wound licking has been shown to promote extraoral wound healing among animals. Although the oral mucosa is bathed in saliva. Little information about the role of saliva in oral wound healing is found. The present study evaluates the healing of extraction wounds in desalivated rats. Experimental rats underwent sialadenectomy of the submandibular and sublingual glands and ligation of the parotid ducts. Maxillary left first molars were extracted. Rats were killed at 0. 1, 3, 5, 7. 10, 14. and 21 days after surgery and maxillae were prepared for light microscopy examination. Generally, a delay in socket healing in the desalivated rats was found. No differences were observed in blood clot formation. Replacement of the clot by granulation tissue was relatively slow concomitant with a longer inflammatory process. Bone formation kinetics were slower among the experimental rats.
Medicina Oral Patologia Oral Y Cirugia Bucal, 2019
Background: The exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is still unknown. The aim of this paper was to investigate the effects of zoledronic acid and dexamethasone on the early phases of socket healing in rats subjected to tooth extractions. Material and Methods: Thirty male Sprague-Dawley rats were divided into 2 groups: pharmacologically treated group (T, n=20) and non-pharmacologically treated group (C, n=10). T group rats received 0.1 mg/Kg of zoledronic acid (ZOL) and 1 mg/Kg of dexamethasone (DEX) three times a week for 10 consecutive weeks. C group rats were infused with vehicle. After 9 weeks from the first infusion, first maxillary molars were extracted in each of the rats. Quantitative macroscopic and microscopic analysis was performed to evaluate socket healing 8 days after extraction. Results: Pharmacologically treated rats showed significant inhibition of bone remodeling. Connective tissue/alveolar bone ratio, osteoclast number and woven bone deposition were significantly reduced in group T compared to group C. Conversely, the proportion of necrotic bone was higher in group T compared to group C (0.8% and 0.3%, respectively. P=0.031). ZOL plus DEX do not cause gross effects on socket healing at a macroscopic level. Conclusions: Our findings confirmed that exposure to ZOL plus DEX impairs alveolar wound repair. Inhibition of osteoclastic resorption of socket walls after tooth extraction and the inability to dispose of the necrotic bone may be considered the initial steps of MRONJ onset.
Effects of 1% and 3% Mobe Leaf Extract Gel on Socket Wound Healing after Tooth Extraction
Dentika: Dental Journal, 2021
Tooth extraction is a process of removing teeth from the alveolar bone. In wound healing, fibroblast are very important cells. The main purpose of this study was to determine the effect of mobe leaf 1% and 3% extract gel (Artocarpus lakoocha) on fibroblast proliferation in post extraction tooth socket wound healing. This research used 16 samples of wistar rats, divided into 4 groups, a positive control group, a negative control group and a 1% and 3% mobe leaf extract gel group. The left mandibular incisors were extracted, then 1% and 3% gels of mobe leaf extract were applied on day 1 to day 7. Data analysis was calculated using the Kruskal-Wallis test on clinical data and one way ANOVA test for microscopic. The result of the socket wound healing activity test for a good concentration of mobe leaf extract gel was 3%. This research shows significant resultith p-value of 0.018 (< 0.05) on the closure of the socket wound clinically which means the closure of the wound accelerates bec...
Journal of orthopaedic surgery (Hong Kong), 2016
To evaluate the effect of povidone iodine and hydrogen peroxide on fracture healing in a rat model. The middle section of the right femur of 36 male Sprague Dawley rats was osteotomised with a saw. In the control group (n=9), the wound was irrigated with 100 ml 0.9% saline. In the 10% povidone iodine (n=9), 1% povidone iodine (n=9), and 3% hydrogen peroxide (n=9) groups, the wound was completely soaked with the respective solution for 2 minutes, and then irrigated with 100 ml saline. The osteotomy was fixed with an intramedullary Kirschner wire. Rats were euthanised at week 1, 2, and 5. In each femur, the percentage area of osseous, cartilaginous, and fibrous tissue in the callus was evaluated in 3 slides (one median and 2 paramedian). The control group differed significantly to the other 3 groups (p=0.023 to p<0.001) in weeks 1, 2, and 5, except for the 1% povidone iodine group in terms of percentage of osseous (p=0.349) and fibrous (p=0.999) tissue. The healing process was simi...
The Impact of Chlorhexidine-based Endodontic Treatment on Periapical Cytokine Expression in Teeth
Journal of Endodontics, 2013
Introduction: Root canal treatment typically involves cleaning and shaping procedures followed by treatment with antibacterial endodontic dressing between appointments and, ultimately, 3-dimensional,hermetic filling. Chlorhexidine (CHX) is effective as an irrigation solution and is used as an endodontic dressing. The aim of this study was to examine the influence of CHX on periapical cytokine expression. Methods: Expression levels of the cytokines interferon g, tumor necrosis factor a, interleukin (IL)-1b, IL-17A, IL-10, and the chemokine monocyte chemoattractant protein-1 (CCL2/MCP-1) were assayed by real-time polymerase chain reaction immediately after root canal cleaning and 15 days later. Results: Messenger RNA expression of IL-1b, interferon g, IL-10, and CCL2/ MCP-1 was increased on day 15 in teeth without endodontic dressing. No statistical change was observed in the messenger RNA expression of cytokines when comparing sampling times for teeth that received endodontic dressing. Conclusions: The results show that CHX application between appointments prevented the increase of both proinflammatory and immunoregulatory cytokines 15 days after the dental procedure. (J Endod 2013;39:889-892)
Advances in wound care, 2017
Objective: To evaluate the wound-healing activity of oil of Hypercium perforatum (St. John's wort), in excision wounds of male white rats. Approach: The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Hyperforin and Hypericin are important phytochemical constituents found in H. perforatum, which have been highlighted for their antimicrobial, antiviral, and anti-inflammatory properties in recent times. Therefore, we have attempted to explore the wound-healing activity of oil obtained from H. perforatum. Results: H. perforatum oil emulsion has been demonstrated to have significant wound-healing potential as compared with mupirocin ointment and petroleum jelly (Vaseline). Animals treated with H. perforatum showed a 97% (18.9 mm 2 /day) reduction in wound area as compared with animals treated with mupirocin (68%) (12.8 mm 2 /day) and animals treated with Vaseline (69%) (13.7 mm 2 /day). X-ray analysis of skin of animals treated with H. perforatum showed a significant increase in angiogenesis as compared with other groups in the study. Innovation: This study identified the wound-healing activity of oil of H. perforatum. Conclusion: The findings of this study support the wound-healing potential of H. perforatum along with other therapeutic uses.