Granuloma annulare: radiographic demonstration of progressive mutilating arthropathy with vanishing bones (original) (raw)
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Dermatology and Dermatitis, 2019
The term granuloma annulare (GA) appropriately describes the classic type characterized by ringed erythematous plaques with histological palisaded granulomatous inflammation. However, GA now includes a range of disease. Over time, more atypical, rare types have been reported in isolated case reports or small case series. Here, we describe a unique case of generalized GA presented by two morphologically different lesions in a 52 years old diabetic man. To the best of our knowledge, this association has never been reported in the literature.
Perforating Granuloma Annulare — An Unusual Subtype of a Common Disease
Healthcare, 2014
Perforating granuloma annulare (GA) is a rare subset of GA with an unknown etiology and chronic course. Herein, we report the case of 72 year-old women with a 3-month history of a post-traumatic, persistent, erythematous and exudative plaque located on her left leg. Differential diagnosis included mycobacterial infection, subcutaneous mycosis, perforating dermatoses, pyoderma and squamous cell carcinoma. The histopathology was highly suggestive of a perforating GA. The patient was treated with betamethasone dipropionate cream applied once daily and a complete resolution of the lesion was observed in three weeks. Despite being a very rare subtype of a common disease, perforating granuloma annulare has clinical and histopathological characteristic features that facilitate the differential diagnosis, avoiding unnecessary procedures and inadequate and potentially more invasive treatments.
Trauma-related papular granuloma annular
Dermatology Online Journal
Granuloma annulare (GA) is a benign, granulomatous disease with several clinical manifestations, which include localized, generalized, perforating, subcutaneous, patch, papular, and linear forms. We report a case of papular GA of the dorsal aspects of the hands that arose after repeated, direct trauma to the site of subsequent involvement. Although multiple etiologies for GA have been proposed, which include ultraviolet light, arthropod bites, trauma, tuberculin skin tests, viral infections, and PUVA photochemotherapy, the underlying pathogenesis of the disorder remains unclear. However, owing to the key histopathologic findings of focal collagen and elastic fiber degeneration and mucin deosition in GA, it is not surprising that cutaneous trauma may have played a role in connective tissue injury, subsequent degeneration, and the production of a granulomatous response with increased mucin deposition.
Disseminated granuloma annulare: study on eight cases
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2013
Granuloma annulare (GA) is classified as localized, generalized/disseminated, subcutaneous, and perforating types. The studies show connection with diabetes mellitus, lipidic metabolic disorders, malignant diseases, thyroid disorders, infections (HBV, HCV, HIV). We performed a retrospective study between 2010-2011, regarding disseminated GA (GAD), and the relationship between GAD and other comorbidities. We clinically and histologically diagnosed eight cases of GAD. The patients were also investigated for the diagnosis of associated diseases. The treatment included topical corticosteroids, antihistamines, Calcipotriol/Betamethasone, Tacrolimus 0.03%, Pentoxifylline, Hydroxychloroquine. Therapeutic response was assessed one month and three months after hospitalization. Our patients were five women and three men, aged 46-68 years, mean age 57.25 years, with a disease history of one year and a half (between three months and four years). The lesions occurred in the upper extremities (ei...
Extensive patch type granulomas annulare: A rare case report
A 16-year-old girl presented with multiple, asymptomatic, progressive, hyperpigmented patches of 6 months duration over trunk and thighs. Histopathology showed features of interstitial granuloma annulare. The clinical diagnosis was consistent with patch type granuloma annulare.
Papular granuloma annulare of palms and soles: case report of a rare presentation
F1000Research, 2014
We report the case of a 44-year-old Indian male patient who presented with mildly tender isolated papular lesions confined to the palms of the hands and soles of the feet. The histopathology was characteristic of granuloma annulare. There was an excellent response with 4-week treatment with a potent topical steroid ointment and no recurrence was reported at the follow-up one year later. This report is interesting because of the rare presentation of a common disease. Sidharth Sonthalia ( ) : Subcutaneous granuloma annulare: a review of 47 cases. Pediatrics. 1997; 100(6): 965-7. PubMed Abstract | Publisher Full Text Penas PF, Jones-Caballero M, Fraga J, et al.: Perforating granuloma annulare. Int J Dermatol. 1997; 36(5): 340-8. PubMed Abstract | Publisher Full Text 6. Gutte R, Kothari D, Khopkar U: Granuloma annulare on the palms: A clinicopathological study of seven cases. Indian J Dermatol Venereol Leprol. 2012; 78(4): 468-74. PubMed Abstract | Publisher Full Text 7. Hsu S, Lehner AC, Chang JR: Granuloma annulare localized to the palms. J Am Acad Dermatol. 1999; 41(2 pt 2): 287-8. PubMed Abstract | Publisher Full Text 8. Imamura S, Ohnishi R, Kawasaki Y, et al.: Long-standing solitary granuloma annulare on the palm of a patient with dermatomyositis. J Dermatol. 2008; 35(5): 304-5. PubMed Abstract | Publisher Full Text 9. Spencer B, Butler D: Painful palmar granuloma annulare responsive to dapsone. J Am Acad Dermatol. 2007; 56(2 suppl 2): AB48. Publisher Full Text 10. Haushalter K, Hughey L, Foster W, et al.: Painful acral nodules as a manifestation of interstitial granuloma annulare. J Am Acad Dermatol. 2007; 56(2 suppl 2): AB57. Publisher Full Text 11. Brey NV, Malone J, Callen J: Acute-onset, painful acral granuloma annulare: a report of 4 cases and a discussion of the clinical and histologic spectrum of the disease. Arch Dermatol. 2006; 142: 49-54. PubMed Abstract | Publisher Full Text 12. Barzegar M, Davatchi CC, Akhyani M, et al.: An atypical presentation of erythema elevatum diutinum involving palms and soles. Int J Dermatol. 2009; 48(1): 73-5. PubMed Abstract | Publisher Full Text 13. Peggy R: Diagnosis and management of granuloma annulare. Am Fam Physician. 2006; 74(10): 1729-34. PubMed Abstract