Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor (original) (raw)

The Journal of Organic Chemistry, 2016

Abstract

The development of a practical asymmetric total synthesis of the potent HIV-1 integrase inhibitor 5 is described. Key transformations include construction of the naphthridine core in a highly efficient manner followed by cyclization of the 8-membered ring. Control of the atropisomers of intermediates and final compound 5 is also described.

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