Amphiphilic per(3,6-anhydro, 2-O-ethyl)-α-cyclodextrin: The first step towards self-gelifying cation cryptants? (original) (raw)

Abstract

The properties of per(3,6-anhydro, 2-O-ethyl)-α-cyclodextrin (3,6-CDE) in solution and in the presence of synthetic membranes were studied by thin layer chromatography, mass, 31P-, 2H- and 1H-NMR spectroscopies, and superficial pressure measurements. It was found that 3,6-CDE exhibits a good affinity for Co2+, Hg2+, Sr2+, Pb2+ and Na+. Besides, ROESY experiments showed that two different conformations of 3,6-CDE were simultaneously present during slow exchange. The tensioactive properties of the soapy solution of 3,6-CDE in water/ethanol were shown by superficial tension (ST) measurements. Moreover, 31P-NMR showed an increase of the superficial fluidity of phospholipid dispersions, above the transition temperature in the presence of 3,6-CDE. Furthermore, no detergent effect was observed in the presence of small unilamellar vesicles of lecithin, membrane destructions being only observed after several days, or when 3,6-CDE and phospholipids were co-sonicated. These results lead to the...

Vincent Dabouis hasn't uploaded this paper.

Let Vincent know you want this paper to be uploaded.

Ask for this paper to be uploaded.