[methyl-3H]Thymidine in DNA induces lesions which are recognized by a mammalian DNA-repair endonuclease (original) (raw)

Research has indicated that [methyl-3H]thymidine causes lesions in DNA that are recognized by mammalian DNA-repair endonucleases. This study builds on previous findings showing the formation of single-stranded breaks in tritium-labeled DNA during storage. The research is focused on characterizing the lesions formed in [methyl-3H]thymidine-labeled DNA and confirming that a specific DNA-repair endonuclease can incise this damaged DNA, suggesting an effective incision-excision repair mechanism that may involve thymine glycol as a potential lesion.