original ) (raw )Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
Gerda Breitwieser
Molecular Endocrinology, 2009
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Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors
Gerda Breitwieser
British Journal of Pharmacology, 2012
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Calcium-sensing Receptor Biosynthesis Includes a Cotranslational Conformational Checkpoint and Endoplasmic Reticulum Retention
Jason McKenna
Journal of Biological Chemistry, 2010
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Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators
Katie Leach
Endocrinology, 2013
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Loss-of-Function and Gain-of-Function Mutations of Calcium-Sensing Receptor: Functional Analysis and the Effect of Allosteric Modulators NPS R-568 and NPS 2143
Kaoru Takegawa
The Journal of Clinical Endocrinology & Metabolism, 2013
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Novel Inactivating Mutations of the Calcium-Sensing Receptor: The Calcimimetic NPS R-568 Improves Signal Transduction of Mutant Receptors
Friedhelm Raue
The Journal of Clinical Endocrinology and Metabolism, 2008
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Rescue of Calcium-sensing Receptor Mutants by Allosteric Modulators Reveals a Conformational Checkpoint in Receptor Biogenesis
Gerda Breitwieser
Journal of Biological Chemistry, 2007
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Excessive Signal Transduction of Gain-of-Function Variants of the Calcium-Sensing Receptor (CaSR) Are Associated with Increased ER to Cytosol Calcium Gradient
Marianna Ranieri , Giovanna Valenti
PLoS ONE, 2013
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Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS …
Friedhelm Raue
Journal of Clinical …
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Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor
Arthur Conigrave
Endocrinology, 2012
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Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant Receptors
Dirk Schnabel
The Journal of Clinical Endocrinology & Metabolism, 2010
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Mutations of calcium-sensing receptor gene: two novel mutations and overview of impact on calcium homeostasis
Adrian Daly
European journal of endocrinology / European Federation of Endocrine Societies, 2011
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Faculty of 1000 evaluation for Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Matilde Colella
F1000 - Post-publication peer review of the biomedical literature, 2016
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Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity
Franck Sturtz
European Journal of Endocrinology, 2013
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Naturally-Occurring Mutation in the Calcium-Sensing Receptor Reveals the Significance of Extracellular Domain Loop III Region for Class C G-Protein-Coupled Receptor Function
Brigitte Blackman
The Journal of Clinical Endocrinology and Metabolism, 2010
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Identification of Serine-875 as an Inhibitory Phosphorylation Site in the Calcium-Sensing Receptor
Lenah Binmahfouz
Molecular Pharmacology, 2019
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Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor
Jacob Jensen
Journal of Pharmacology and Experimental Therapeutics, 2011
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Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane Domain
Martial Ruat
Journal of Biological Chemistry, 2004
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Pharmacology of the calcium sensing receptor
S. Corbetta
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2013
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Calcium-sensing receptor 20 years later
ahmad saleh
American journal of physiology. Cell physiology, 2014
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Human Calcium-sensing Receptor Gene
Lucie Canaff
Journal of Biological Chemistry, 2002
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Residue 826 in the Calcium-Sensing Receptor Is Implicated in the Response to Calcium and to R-568 Calcimimetic Compound
Isabel Rodríguez
Calcified Tissue International, 2010
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Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Katie Leach
British journal of pharmacology, 2015
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The Calsequestrin Mutation CASQ2D307H Does Not Affect Protein Stability and Targeting to the Junctional Sarcoplasmic Reticulum but Compromises Its Dynamic Regulation of Calcium Buffering
Clara Franzini-armstrong
Journal of Biological Chemistry, 2010
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Dimerization of the Calcium-sensing Receptor Occurs within the Extracellular Domain and Is Eliminated by Cys right-arrow Ser Mutations at Cys101 and Cys236
Gerda Breitwieser
Journal of Biological Chemistry, 1999
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A novel mutation in the Calcium-Sensing Receptor in a French family with Familial Hypocalciuric Hypercalcaemia
Abdallah Salameh
European Journal of …, 2011
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The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation: relevance to autosomal dominant hypocalcemia type 1 (ADH1)
Andrew Nesbit
Endocrinology, 2015
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Calcium Sensing Receptor Activation by a Calcimimetic Suggests a Link between Cooperativity and Intracellular Calcium Oscillations
Gerda Breitwieser
Journal of Biological Chemistry, 2002
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Biased agonism of the calcium-sensing receptor
manohar modak
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Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms
Katie Leach
Molecular pharmacology, 2018
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