Central Glucocorticoid Receptor Immunoreactive Neurons: New Insights into the Endocrine Regulation of the Brain (original) (raw)
Abstract
AI
This paper investigates the distribution and significance of central glucocorticoid receptor (GR) immunoreactive neurons in the brain, particularly focusing on their role in chemical transmission. It examines both wiring and volume transmission aspects in the central nervous system and highlights the importance of glucocorticoids as peripheral signals influencing neuronal communication. Insights into their effects on specific brain regions, such as the thalamus and hypothalamus, suggest a crucial role for GR in the regulation of neuronal activity and endocrine signaling.
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References (60)
- ACNATI, L. F., K. FUXE, M. ZOLI, E. MERLO PICH, F. BENFENATI, I. ZINI & M. GOLDSTEIN. 1986. Aspects on the information handling by the central nervous system: focus on cotransmission in the aged rat brain. In Progress in Brain Research. T. Hokfeit, K . Fuxe & B. Pernow, Eds. Vol. 6 8 291-301. Elsevier Science Publishers B V (Biomedical Division). Amsterdam.
- AGNATI, L. F., K. FUXE, M. ZOLI, 1. ZINI, G . TOFFANO & F. FERRACUTI. 1986. A 3.
- correlation analysis of the regional distribution of central enkephalin and @-endorphin immunoreactive terminals and of opiate receptors in adult and old male rats. Evidence for the existence of two main types of communication in the central nervous system: the volume transmission and the wiring transmission. Acta Physiol. Scand. 128: 201-207.
- NICHOLSON, C. 1980. Measurements of extracellular ions in the brain. TINS 215-218.
- MCEWEN, B. 1982. Glucocorticoids and hippocampus: Receptors in Search of a Function. In Adrenal Actions on Brain. D. Ganten & D. Pfaff, Eds. 1-22. Springer-Verlag. Berlin.
- AGNATI, L. F., K. FUXE, D. KUONEN, C. A. BLAKE, K. ANDERSON, P. ENEROTH, J.-p\. GUSTAFSSON, N. BATTISTINI & L. CALZA. 198 I . Effects of estrogen and progesterone on Central a-and 0-adrenergic receptors in ovariectomized rats. Evidence for gonadal steroid receptor regulation of brain a-and @-adrenergic receptors. In Steroid Hormone Regulation of the Brain. K Fuxe, J.-p\. Gustafsson & L. Wetterberg, Eds. 237-252. Pergamon Press. Oxford.
- MCEWEN, B. S., J. M. WEISS & L. S. SCHWARTZ. 1969. Uptake of corticosterone by rat brain and its concentration by certain limbic structures. Brain Res. 1 6 227-241.
- MCEWEN, B. S., R. E. ZIGMOND, E. C. AZMITIA, JR. & J. M. WEISS. 1970. Steroid hormone interaction with specific brain regions. In Biochemistry of Brain and Behavior.
- STUMPF, W. E. & M. SAR. 1975. Anatomical distribution of corticosterone concentrating neurons in rat brain. In Anatomical Neuroendocrinology. W. E. Stumpf & L. D. Grants, Eds., 254-261. Karger. Basel.
- STUMPF, W. E. & M. SAR. 1981. Steroid hormone sites of action in the brain. In Steroid Hormone Regulation of the Brain. K. Fuxe, J.-p\. Gustafsson & L. Wetterberg, Eds. 41-50. Pergamon Press. Oxford.
- AGNATI, L. F., K. FUXE, Z.-U. Yu, A. HARFSTRAND, S. OKRET, A.-C. WIKSTROM, M. GOLDSTEIN, M. ZOLI, W. VALE & J.-p\. GUSTAFSSON. 1985. Morphometrical analysis of the distribution of corticotrophin releasing factor, glucocorticoid receptor and phenyle- thanolamine-N-methyltransferase immunoreactive structures in the paraventricular hypothalamic nucleus of the rat. Neurosci. Lett. 5 4 147-152.
- FUXE, K., A.-C. WIKSTROM, S. OKRET, L. F. AGNATI, A. HARFSTRAND, Z.-Y. Yu, L. GRANHOLM, M. ZOLI, W. VALE & J.-p\. GUSTAFSSON. 1985. Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel-and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor. Endocrinology 177(5): 1803-1 8 12.
- FUXE, K., A. HARFSTRAND, L. F. AGNATI, Z.-Y. Yu, A. CINTRA, A,-C. WIKSTROM, S. OKRET, E. CANTONI & J.-p\. GUSTAFSSON. 1985. Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorti- coid receptor. Neurosci. Lett. 6 0 1-6.
- FUXE, K., L. F. AGNATI, A. HARFSTRAND, A,-C. WIKSTROM, S. OKRET, Z.-Y. Yu, M. GOLDSTEIN, A. CINTRA, A. M. JANSON, M. ZOLI, L. S. MILLER, J. L. GREEN & J.-p\. GUSTAFSSON. 1985. Morphofunctional studies on central glucocorticoid and estrogen receptors: new openings for the understanding of the hormone regulation of brain function. Table Ronde, Roussel Uclaf No. 53 17-21.
- FUXE, K., A. CINTRA, L. F. AGNATI, A. HARFSTRAND, A.-C. WIKSTROM, M. ZOLI, L. S. MILLER, G. L. GREENE & J.-A. GUSTAFSSON. 1987. Studies on the cellular localization and distribution of glucocorticoid receptor and estrogen receptor immunoreactivity in the central nervous system of the rat and their relationship to the monoaminergic and peptidergic neuorons of the brain. J . Steroid. Biochem. In press.
- CINTRA, A., K. FUXE, A. HARFSTRAND, L. F. AGNATI, A.-C. WIKSTROM, W. VALE & J.-A. GUSTAFSSON. 1987. Evidence for the presence of glucocorticoid receptor immunoreactiv- ity in corticotrophin releasing factor and in growth hormone releasing factor immunore- active neurons of the rat di-and telencephalon. Neurosci. Lett. 7 6 269-274.
- HARFSTRAND,A., K. FUXE, A. CINTRA, L. F. AGNATI, I. ZINI, A.-C. WIKSTROM,S. OKRET, 2.-Y. Yu, M. GOLDSTEIN, W. STEINBUSH, A. VERHOFSTAD & J.-p\. GUSTAFSSON. 1986. Demonstration of glucocorticoid receptor immunoreactivity in monoamine neurons of the rat brain. Proc. Natl. Acad. Sci. USA 8 3 9779-9783.
- ANTAKLY, T. & H. J. EISEN. 1984. Immunocytochemical localization of glucocorticoid receptor in target cells. Endocrinology 115: 1984-1989.
- OKRET, S., A,-C. WIKSTROM, 0. WRANGE, B. ANDERSSON & J.-A. GUSTAFSSON. 1984. Monoclonal antibodies against the rat liver glucocorticoid receptor. Proc. Natl. Acad. Sci. USA81: 1609-1613.
- WIKSTROM, A,-C. 1986. Production and use of monoclonal antibodies against the glucocor- ticoid receptor. M.D., ISBN 91-7900-087-8. Repro Print AB. Stockholm.
- HOKFELT, T., K. FUXE & B. PERNOW. 1986. Coexistence of neuronal messengers: a new principle in chemical transmission. Prog. Brain Res. 68: 1-403.
- WESSENDORF, M. & R. ELDE. 1985. Characterization of an immunofluorescence technique for the demonstration of coexisting neurotransmitters within nerve fibers and terminals. J. Histochem. Cytochem. 10: 984-994.
- WIKSTROM, A.-C., 0. BAKKE, S. OKRET, M. BRONNEGARD & J.-A. GUSTAFSSON. 1986. lntracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization. Endocrinology. Submitted.
- CINTRA, A,, K. FUXE, A. HARFSTRAND, L. F. AGNATI, L. S. MILLER, J. L. GREENE & J.-A. GUSTAFSSON. 1986. On the cellular localization and distribution of estrogen receptors in the rat tel-and diencephalon using monoclonal antibodies to human estrogen receptor. Neurochem. Int. 8(4): 587-595.
- REUL, J. M. & E. R. DE KLOET. 1986. Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis. J. Steroid Biochem. 24(1): 269-272.
- TOWLE, A. C . , P. Y. SZE & J. M. LAUDER. 1982. Cytosol glucocorticoid binding in monoaminergic cell groups. Dev. Neurosci. 5: 458-463.
- DUNCAN, G . E. & W. E. STUMPF. 1985. A combined autoradiographic and immunocyto- chemical study of 'H-corticosterone target neurons and catecholamine neurons in rat and mouse lower brain stem. Neuroendocrinology 4 0 262-27 1.
- FUXE, K., L. F. AGNATI, A. HARFSTRAND, A. CINTRA, M. ARONSSON, M. ZOLI & J.-A. GUSTAFSSON. 1985. Principles for the hormone regulation of wiring and volume transmis- sion in the central nervous system. In Current Topics in Neuroendocrinology, Vol. 8, "Neuroendocrinology of Mood." D. Ganten, Ed. Springer-Verlag. Berlin. In press.
- BOHN, M. C., M. GOLDSTEIN & 1. B. BLACK. 1986. Expression and development of phenylethanolamine-N-methyltransferase (PNMT) in rat brain stem: studies with glucocorticoids. Dev. Biol. 114 180.
- HARFSTRAND, A,, K. FUXE, L. F. AGNATI, P. ENEROTH, I. ZINI, M. ZOLI, K. ANDERSON, G. VON EULER, L. TERENIUS, V. MUTT & M. GOLDSTEIN. 1986. Studies on neuropeptide Y-catecholamine interactions in the hypothalamus and in the forebrain of the male rat. Relationship to neuroendocrine function. Neurochem. lnt. 8: 355-376.
- HARFSTRAND, A,, P. ENEROTH, L. F. AGNATI & F. FUXE. 1987. Further studies on the effects of central administration of neuropeptide Y on neuroendocrine function in the male rat: relationship to hypothalamic catecholamines. Regul. Peptides 17: 167-1 79.
- HENKIN, R. I. 1975. Effects of ACTH, adrenocorticosteroids and thyroid hormone in sensory function. In Anatomical Neuroendocrinology. W. Stumpf & L. Grant, Eds. 298-316. Karger. Basel.
- DAHL, L. U., M. HEINE & L. TASSINARI. 1963. Effects of chronic excess salt ingestion: role of genetic factors in both DOCA-salt and renal hypertension. J. Exp. Med. 118: 605.
- FUXE, K., L. F. AGNATI, M. KALIA, M. GOLDSTEIN, K. ANDERSON & A. HARFSTRAND. Dopaminergic systems in the brain and pituitary. In Basic and Clinical Aspects of Neuroscience: The Dopaminergic System. E. Fliickiger, F. E. Miiller & M. 0. Thorner, Eds. 11-25. Springer-Verlag.
- BAI, F. L., M. YAMANO, Y. SHIOTANI, P. C. EMSON, A. D. SMITH, J. F. POWELL & M. TOHYAMA. 1985. An arcuato-paraventricular and dorsomedial hypothalamic neuropep- tide Y containing system which lacks noradrenaline in the rat. Brain Res. 331: 172-175.
- KHACHATURIAN, H., M. E. LEWIS, K. TSOU & S. J. WATSON. 1985. /3-Endorphin, a-MSH, ACTH, and related peptides. In Handbook of Chemical Neuroanatomy, Vol. 4, GABA and Neuropeptides in the CNS, Part I. A. Bjorklund & T. Hokfelt, Eds. 216-272. Elsevier Science Publishers B.V. Amsterdam.
- FEKETE, M. I., B. KANYICSKA, T. SZENTENDREI & E. STARK. 1984. Loss of sensitivity to morphine induced by prolonged ACTH treatment. Pharmacol. Biochem. Behav. 2 0 879- 882.
- FEKETE, M. I. K., B. KANYICSKA, T. SZENTENDREI, A . SIMOYI & E. STARK. 1984. Decrease of morphine-induced prolactin release by a procedure causing prolonged stress. J. Endocrinol. 101: 169-172.
- FERLAND, L., K. FUXE, P. ENEROTH, J.-A. GUSTAFSSON & P. SKETT. 1977. Effects of methionine-enkephaline on prolactin release and catecholamine levels and turnover in the median eminence. Eur. J. Pharmacol. 4 3 89-90.
- FUXE, K., L. FERLAND, K. ANDERSON, P. ENEROTH, J.-A. GUSTAFSSON & P. SKETT. 1978. On the functional role of hypothalamic catecholamine neurons in control of the secretion of hormones from the anterior pituitary, particularly in the control of LH and prolactin secretion. In Brain-Endocrine Interaction. 111. Neural hormones and rcproduction. D. E. Scott, G. P. Kozlowski & A. Weindl, Eds. 172-182. Karger. Basel.
- FUXE, K., K. ANDERSON, V. LOCATELLI, V. MUTT, J . LUNDBERG, T. HOKFELT, L. F. AGNATI, P. ENEROTH & P. BOLME. 1980. Neuropeptides and central catecholamine systems: interactions in neuroendocrine and central cardiovascular regulation. In Neural Peptides and Neuronal Communication. E. Costa & M. Trabucchi, Eds. 37-50. Raven Press. New York, NY.
- FUXE, K . & G. SEDVALL. 1981. Pharmacological and clinical implications of chemical neurotransmission: Chairmen's overview. In Chemical Neurotransmission. L. Stjarne, P. Hedqvist, H. Lagercranz & A. Wennrnalrn, Eds. 541-548. Academic Press. London.
- SUTTON. R. E., G. F. KOOL, M. LEMOAL, R. RlVlER & W. VALE. 1982. Corticotropin- releasing factor produces behavioural activation in rats. Nature (London) 293: 319- 336.
- KALRA, S. P. & P. S. KALRA. 1983. Neural regulation of luteinizing hormone secretion in the rat. Endocrin Rev. USA 4: 31 1-35],
- GERLACH, J . L. & B. MCEWEN. 1972. Rat brain binds adrenal steroid hormone: radioaut- ography of hippocampus with corticosterone. Science 175: 1133-1 136.
- SAPOLSKY, R. M. 1985. Mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults. J. Neurosci. 5: 1222-1227.
- SAPOLSKY, R. M., L. KREY & B. MCEWEN. 1983. Corticosterone receptors decline in a site-specific manner in the aged rat brain. Brain Res. 289: 235-240.
- FUXE, K., T. HOKFELT & U. UNGERSTEDT. 1971. Localization of monoamines in the central nervous system. In Monoamines Noyaux Gris Centraux et Syndrome de Parkinson. J. de Ajuriaguerra & G. Gauthier, Eds. 23-60. Georg et Cie., SA. Genke.
- OLSON, L., A. SEIGER & K. FUXE. 1972. Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats. Brain Res. 4 4 283- 288. TENNYSON, V. M., R. E. BARRETT, G. COHEN, L. COTE, R. HEIKKILA & C. MYTILINFOU. 1972. The developing neostriatum of the rabbit: correlation of fluorescence histochemis- try, electron microscopy, endogenous dopamine levels, and 'H-dopamine uptake. Brain Res. 4 6 251-285.
- GRAYBIEL, A. M. 1986. Dopamine-containing innervation of the straitum: subsystems and their striatal correspondents. In Recent Developments in Parkinson's Disease. S. Fahn, C. D. Marsden, P. Jenner & P. Teychenne, Eds. 1-32. Raven Press. New York, NY.
- GERFEN, C. R. 1987. The neostriatal mosaic: the reiterated processing unit. In Neurotrans- mitter Interactions in the Basal Ganglia. M. Sandler, C. Feuersein & B. Scatton, Eds. 19-29.
- AGNATI, L. F., K. FUXE, M. ZOLI, F. FERRAGUTI, F. BENFENATI, C. QUIMET, I . WALAAS, M. GOLDSTEIN & P. GREENGARD. 1987. Morphometrical analysis of tyrosine-hydroxy- lase enkephalin and DARPP-32 like immunoreactive profiles and their codistribution at three rostrocaudal levels of the rat neostriatum. Evidence for a complex islandic and striae organization. Neuroscience. Submitted.
- FUXE, K., L. F. AGNATI, M. ZOLI, A. HARFSTRAND, S.-0. OGREN, E. MERLO PICH, I. ZINI & M. GOLDSTEIN. 1987. Morphometrical and rnicrodensitornetrical studies on the mosaic organization of the striatum. Focus on neuropeptide/dopamine transmitter interactions at the pre-and postsynaptic level. In Neurotransmitter Interactions in the Basal Ganglia. M. Sandler, C. Feuerstein & B. Scatton, Eds. 31-36.
- HERKENHAM, M., S. MOON EDLEY & J. STUART. 1984. Cell clusters in the nucleus accumbens of the rat, and the mosaic relationship of opiate receptors, acetylcholinester- ase and subcortical afferent terminations. Neuroscience ll(3): 561-593.
- ZOLI, M., L. F. AGNATI, K. FUXE, I. ZINI, A. CINTRA, M. ARONSSON, A. HARFSTRAND & J.-A. GUSTAFSSON. 1987. Evidence for the existence of a humoral mosaic organization in the dorsal striatum and nucleus accumbens of the male rat: studies on glucocorticoid receptor immunoreactive nerve cells. Brain Res. Submitted.
- KANYICSKA, B., A SIMONYI, L. G. HARSING JR., E. SZILVESZTER VIZI, 1. MARTON, K. FEKETE & E. STARK. 1985. Catalepsy, hypermotility, increase of striatal acetylcholine release induced by morphine and met-enkephalin is affected by prolonged hydrocortisone and ACTH treatment. Pol. J. Pharmacol. Pharm. 37: 437-443.
- WOLKOWITZ, O., M. SUTTON, M. KOUISJ, R. LABARCA, L. WILKINSON, A. DORAN, R. HAUGER, D. PICKAR & J. CRAWLEY. 1986. Chronic corticosterone administration in rats: behavioral and biochemical evidence of increased central dopaminergic activity. Eur. J. Pharmacol. 1 2 2 329-338.
- ZOLI, M., L. F. AGNATI, K. FUXE, 1. Z I N I , E. MERLO PICH, R. GRIMALDI, A. HARFSTRAND, A. C. WIKSTROM & J.-A. GUSTAFSSON. 1987. Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase and neuropeptide Y immunoreac- tive nerve terminals and on glucocorticoid receptor immunoreactive nerve cell nuclei in the paraventricular hypothalamic nucleus in adult and old male rats. Neuroscience. Submitted.
- KITAYAMA, I., A. M. JANSON, A. CINTRA, K. FUXE, L. F. AGNATI, S.-0. OGREN, A. HARFSTRAND, P. ENEROTH & J.-A. GUSTAFSSON. 1987. Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain. J . Neural. Transm. In press.
- HALL, R. C. W., M. K. POPKIN & B. KIRKPATRICK. 1978. Tricyclic cxacerbation of steroid psychosis. J. Nerv. Ment. Dis. 166: 738-742.