314. Interleukin-6 in Patients with Systemic Sclerosis: The Association with Lung Involvement in High Resolution Computer Tomography, Type of Disease, Selected Inflammatory and Serological Parameters (original) (raw)

RR) 7.88, 95% CI 4.10, 15.17, P < 0.0001; late: 8% vs 1% respectively, RR 9.96, 95% CI 1.88, 52.87, P ¼ 0.0081). Ab positivity was associated with abnormal NFC (P ¼ 0.025 for any Ab, P ¼ 0.019 for ANA, P < 0.001 for ACA). The RR of detecting a SSc NFC pattern (early/active/late) if ANA or ACA þve was 1.88 (1.16, 3.05, P ¼ 0.0067) and 2.59 (95% CI 1.80, 3.72, P < 0.001) respectively. A history of previous DU in sRP was also associated with abnormal NFC (P ¼ 0.015) and SSc NFC pattern (RR 2.59, 95% CI 1.70, 3.96, P ¼ 0.0037). Abþve with a SSc NFC pattern conferred an OR of SSc-sRP of 11.03 (95% CI 4.81, 25.77, P < 0.0001); early: 3.22 (95% CI 1.24, 8.15, P < 0.0119), active: 7.6 (95% CI 2.87, 20.56, P < 0.0001), late: 7.12 (95% CI 0.97, 80.25, P < 0.0273). Conclusion: NFC abnormalities are commonly seen in RP of any cause, however active and late vasculopathy patterns are rarely visualized in RP not related to SSc. Presence of Ab or previous DU is associated with abnormal NFC. Presence of Ab with SSc NFC pattern greatly increases odds of having SSc-related sRP.