L'artériographie fœtale : apport à l'étude embryogénique des malformations (original) (raw)

Revue Française des Laboratoires, 1998

Abstract

ABSTRACT Sirenomelia is a very rare malformation where etiology remains unclear. While the compression theory is now rejected by most authors, two hypotheses are still discussed : 1/ a caudal dysgenesis as part of the caudal regression syndrome and 2/ a vascular disruption : the aberrant umbilical artery would divert the blood flow from the caudal portion of the embryo to the placenta. We have analyzed the arterial vasculature of three sirenomelic fetuses by means of arteriography. The caudal arterial network differs clearly from one fetus to the other ; mainly, the higher the aberrant umbilical artery arises from the aorta, the more severe is the disturbance of the caudal development. These findings support the vascular disruption theory to explain the etiology of sirenomelia.

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