The cytochrome P-450 Substrate optical difference spectra of pesticides with mouse hepatic microsomes (original) (raw)

The study investigates the binding interactions of various pesticides with cytochrome P-450 enzymes in mouse hepatic microsomes, focusing on the optical difference spectra alterations caused by these substances. Notable changes in the Soret band are examined to categorize the compounds’ interactions as type I or type II, which are distinguished by their specific optical properties at various wavelength peaks and troughs. The findings indicate the complexity and implications of pesticides on non-target species' hepatic enzyme function.