Malakoplakia (original) (raw)

Malakoplakia, Genitourinary Tract

Encyclopedia of Pathology, 2020

Soft yellow plaque Definition It is an inflammatory lesion resulting in histiocytic accumulation, which is related to impaired intraphagosomal digestion. Clinical Features • Incidence Uncommon lesion associated with E. Coli bacterial infection. It may be related to concurrent acute inflammation and immunosuppression (Long and Althausen 1989). Macroscopy The majority of reported cases are multiple soft yellow or yellow-brown plaques, nodules, or polypoid lesions, with less than 2 cm in greatest dimension. In the kidney the nodules may be larger and involve the entire kidney.

Pathology of tumours of the urinary tract

Surgery (oxford), 2008

Attention is called to the difference between the pathologist's and the radiologist's point of view. The reasons for this difference are discussed with special emphasis on renal tumours. Classification of renal tumours. The first main groups are innocent and malignant. Are these really clear-cut or do they blend into one another ? The commoner innocent renal tumours are adenoma, fibroma, myoma, lipoma, and angioma. These are rarely of any clinical importance but adenoma is a possible source of hypernephroma. AMany elaborate classifications of cancer of the kidney have been proposed but the following four groups are sufficient for most purposes: Carcinoma, hypernephroma, sarcoma, and teratoid tumours. Much the commonest malignant renal tumour in adults is the hypernephroma, thought by Grawitz and others to be derived from ectopic adrenal rests. There is still no agreement concerning their origin but three views are held at the present time : (a) All are carcinoma of renal tubules. (b) Some are derived from renal tubules and some from ectopic adrenal. (c) All are formed from adrenal tissue. These views are discussed with special reference to material in St. Mary's Hospital Museum, and it is suggested that the first view is the most probable although the second cannot be excluded. The teratoid tumours are the commonest in infants and swine. The differences between them and hypernephromata are described. The renal pelvis, ureter, and bladder all have tumours of the same type and can conveniently be considered together. Connective tissue tumours, both innocent and malignant, are very rare. Papilloma and carcinoma are rare in the pelvis and ureter, but commoner in the bladder. The relation between these two tumours is discussed. REsuME.-L'auteur attire l'attention sur la difference entre les points de vue pathologique et radiologique, et en discute les causes, mentionnant en particulier les tumeurs du rein. Classification des tumeurs du rein. Les deux groupes principaux sont les tumeurs benignes et les tumeurs malignes. Ces groupes sont-ils vraiment distincts, ou se fondent-ils l'un dans l'autre ? Les tumeurs b6nignes les plus fr6quentes sont les ad6nomes, les fibromes, les myomes, les lipomes et les angiomes. Elles ont rarement une importance clinique, quoique l'adenome peut etre le point de depart d'un hypernephrome. Beaucoup de classifications 6labor6es des cancers du rein ont ete proposees, mais les quatre groupes suivants suffisent pour la plupart des cas: le carcinome, l'hypernephrome, le sarcome et les tumeurs teratoides. Chez les adultes, la tumeur maligne de beaucoup la plus fr6quente est l'hypern6phrome, que Grawitz, entre autres, a consider6 comme d6riv6 de restes ectopiques de glande surr6nale. Les auteurs ne s'accordent pas encore sur l'origine de ces tumeurs, mais trois opinions sont tenues aujourd'hui: (a) elles sont toujours des carcinomes des tubules r6nales, (b) quelques-unes derivent des tubules r6nales et d'autres de restes surr6naux, (c) elles derivent toujours du tissu surrenal. Ces opinions sont discutees ici avec allusion speciale au mat6riel du musee de l'H6pital de St. Mary. L'auteur suggere que la premiere theorie est la plus probable, mais que la seconde possibilite ne peut pas etre exclue. Chez les nourrissons et le porc les tumeurs les plus frequentes sont les tumeurs teratoides. L'auteur decrit les differences entre ces tumeurs et les hypernephromes. Le bassinet, l'uretere SEPT.-RAD. 1

Malakoplakia mimics urinary bladder cancer: A case report

Vojnosanitetski pregled, 2013

Introduction. Malakoplakia is an unusual and very rare chronic inflammatory disease. In bladder especially it can mimic malignancy and lead to serious misdiagnosis. Case report. We presented a case of a middle-aged woman with persistent macrohematuria and cystoscopically polypoid bladder mass that resembled a neoplastic process. The final diagnosis was based on cystoscopic biopsy and microscopic findings of acidophilic, foamy histiocytes with the presence of Michaelis-Gutmann inclusions which are characteristic for diagnosis of malakoplakia. Immunohistochemistry confirmed diagnosis by demonstrating CD68-positive macrophages. Conclusion. Urinary bladder malakoplakia should be considered in patients with persistent urinary tract infections and tumor mass at cystoscopy. Early identification with prompt antibiotic treatment can be helpful in avoiding unnecessary surgical interventions and in preventing development of possible complications.

Malakoplakia of the bladder associated with advanced obstructive uropathy

Malakoplakia is an inflammatory condition that rarely occurs in the urogenital tract. The most frequently affected organ is the urinary bladder, while involvement of the testis is extremely rare. This condition has the features of a granulomatous inflammation. In this article we present a case of bladder malakoplakia associated with advanced obstructive uropathy.

Renal Failure Caused by Malakoplakia Lesions of the Urinary Bladder

Μalakoplakia is a rare inflammatory condition of the urogenital tract. The most frequently affected organ is urinary bladder. This condition has features of a granulomatous inflammation, the pathogenesis of which is not well understood. In this study, we presented a case of urinary bladder malakoplakia associated with advanced obstructive uropathy and renal failure.

Sonographic appearance of bladder malacoplakia

Pediatric Radiology, 2003

We report sonographic features of bladder malacoplakia (multiple polypoid solid masses) in a 16-year-old girl with Russell-Silver syndrome who presented with renal failure and urinary tract infection.

A Case of Malakoplakia Mimicking Prostatic Malignancy

Annals of Pathology and Laboratory Medicine, 2020

Malakoplakia is a granulomatous inflammatory condition commonly involving the urogenital tract. Principally it involves the urinary bladder, prostate is a rare site. Clinical and radiological examination sometimes mimics malignancy. Histology remains confirmatory modality for the diagnosis. Hereby we report a case of prostatic malakoplakia in an elderly male who presented with lower urinary tract symptoms in the past fifteen days. Urine routine microscopy showed pus cells; culture report was positive for E. coli. Serum Prostate Specific antigen (PSA) was 4.6 ug/ml. Magnetic Resonance Imaging (MRI) showed a bulky prostate. A 12-core biopsy was done to rule out malignancy and the histopathology showed benign prostatic glands and the stroma with a predominant population of epithelioid histiocytes and the characteristic Michealis-Gutmann bodies. After a course of antibiotic Nitrofurantoin, transrectal ultrasound was repeated which showed reduction in the prostatic volume. Subsequently Trans-Urethral Resection of Prostate (TURP) was done to relieve the persistent lower urinary tract symptoms. Histology showed similar features. Special stains-Von kossa and Prussian Blue highlighted the Michealis-Gutmann bodies.

Pseudotumoral malacoplakia of the bladder

African Journal of Urology, 2009

Malacoplakia is a rare inflammatory condition most often affecting the genitourinary system. We report the case of a 24-year-old man who presented with gross hematuria, nocturia, frequency, dysuria and considerable weight loss during the preceding three months. Digital rectal examination showed a solid pelvic mass. Ultrasonography and computed tomography showed calyceal dilatation on the right side and a solid bladder mass 10 cm in diameter suspicious of bladder cancer. Transurethral resection of the tumor was incomplete, due to the large volume of the bladder mass. Histological examination of the resected specimen revealed malacoplakia of the bladder. The patient was treated with fluoroquinolone and vitamin C. Follow-up at 3 months showed marked regression of the bladder mass and complete resolution of the calyceal dilatation.