Contact activation during incubation of five different polyurethanes or glass in plasma (original) (raw)

The study investigates the activation of contact factors in the coagulation pathway when polymeric materials are incubated with plasma. Five different polyurethanes, including two commercially available and three custom-synthesized, were tested against glass to measure their ability to activate contact factors such as factor XII and prekallikrein. Results indicated that custom polyurethanes activated the contact system less effectively than commercial types, and contact activation was influenced by the ratio of material surface area to plasma incubation volume.