Synthetic Communications An International Journal for Rapid Communication of Synthetic Organic Chemistry Green Process Development for the Synthesis of Aliphatic Symmetrical N,N′-Disubstituted Thiourea Derivatives in Aqueous Medium (original) (raw)

The development of environmentally friendly synthesis processes in organic chemistry has increased focus on water-based reactions. This work presents a novel strategy for synthesizing aliphatic symmetrical N,N′-disubstituted thiourea derivatives leveraging primary aliphatic amines and carbon disulfide without catalysts. Significant emphasis is placed on achieving high yield and efficiency, particularly under room temperature conditions, contributing to the advancement of green chemistry methodologies.