Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-infl ammatory, Analgesic, Antipyretic and Ulcerogenic Potential (original) (raw)

As a part of ongoing studies in developing new potent anti-infl ammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was effi ciently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-infl ammatory activities using carrageenin- induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic eff ects. Among the synthesized compounds, thiourea derivative ( 6a, e ) exhibited higher anti-infl ammatory activity than the standard drug naproxen in reduction of the rat paw edema ( 88.71, 89.77 % ) respectively. All of the non-carboxylic tested compounds were found to have promising anti-infl ammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic eff ects.

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