Obstructive Sleep Apnea and Subclinical Interstitial Lung Disease in MESA (original) (raw)

Annals of the American Thoracic Society, 2017

Abstract

Obstructive sleep apnea (OSA) has been postulated to contribute to idiopathic pulmonary fibrosis by promoting alveolar epithelial injury via tractional forces and intermittent hypoxia. To determine whether OSA is associated with subclinical interstitial lung disease (ILD) and with biomarkers of alveolar epithelial injury and remodeling. We performed cross-sectional analyses of 1,690 community-dwelling adults who underwent 15-channel in-home polysomnography and thoracic computed tomography (CT) imaging in the Multi-Ethnic Study of Atherosclerosis. We measured the obstructive apnea-hypopnea index (oAHI) from polysomnography and high attenuation areas (HAA) and interstitial lung abnormalities (ILA) from CT. Serum matrix metalloproteinase-7 (MMP-7) and surfactant protein-A (SP-A) were measured by ELISA in 99 participants. We used generalized linear models to adjust for potential confounders. The mean age was 68 years, and the mean forced vital capacity was 97% predicted. The median oAHI...

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