3) Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors an overview (2009–2016).pdf (original) (raw)

This review article provides a comprehensive overview of the structure-activity relationships (SAR) related to the synthesis of selective cyclooxygenase-2 (COX-2) inhibitors, focusing on research from 2009 to 2016. It discusses the mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly their selective inhibition of COX-1 and COX-2 enzymes, and highlights the development of coxibs as safer alternatives with reduced gastrointestinal side effects. The article also presents experimental data on the potency and selectivity of various COX-2 inhibitors, suggesting future directions for the design of new anti-inflammatory agents.