Migraine CVD Cephlalgia 2011.pdf (original) (raw)
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Background: To investigate the association between cardiovascular risk-factor profile and migraine in the elderly, we evaluated a population sample of ageing men and women (65 years or more) living in a low-income area in the city of São Paulo, Brazil. Patients and Methods: We investigated migraine status and cardiovascular profile from a baseline of 1450 participants (65-102 years of age) of the São Paulo Ageing & Health Study (SPAH), a longitudinal population-based study with lowincome elderly in Brazil. The following age and sex-adjusted cardiovascular risk factors were analyzed: blood pressure, pulse pressure, serum total and high-density lipoprotein cholesterol, body mass index, smoking, history of hypertension, diabetes and the 10-year risk of myocardial infarction or coronary heart disease death based on the Framingham Risk Score. Results: The overall prevalence of migraine was 11.4%, and it was 3 times more frequent among women than men (15.3% vs 5.4%; P < 0.0001). Migraineurs were younger than non-migraineurs (mean age 70.6 years vs 72.1 years; P ¼ 0.001, respectively). There was no statistically significant difference regarding the cardiovascular risk-factor profile after adjustment for age and sex among migraineurs and non-migraineurs. Only a decrease in the risk of hypertension among women (OR 0.58; 95% CI 0.38-0.90; P ¼ 0.01) was also observed even after adjustment for age. Conclusions: Overall, we did not find a worse cardiovascular risk profile among elderly migraineurs. An inverse association between hypertension and migraine in women warrants further investigation.
Migraine and cardiovascular disease: A population-based study
Neurology, 2010
Objectives: Although the relationship between migraine and cardiovascular disease (CVD) has been studied, several questions remain unanswered. Herein we contrast the rate of diagnosed CVD as well as of risk factors for CVD in individuals with migraine with and without aura (MA and MO) and in controls.
A Comprehensive Assessment of Vascular and Nonvascular Risk Factors Associated with Migraine
Cureus
Introduction: Migraine is a chronic disabling neurological disease, with an estimated expense of $15-20 million/year. Several studies with a small number of patients have studied risk factors for migraine such as cardiovascular disorders, stroke, smoking, demographic, and genetic factors but this is the first comprehensive study for evaluation of vascular and nonvascular risk factors. It is important to evaluate all the risk factors that help to prevent the healthcare burden related to migraine. Methodology: We performed a retrospective cross-sectional analysis of the Nationwide Inpatient Sample (NIS) (years 2013-2014) in adult (>18-years old) hospitalizations in the United States. Migraine patients were identified using ICD-9-CM code to determine the demographic characteristics, vascular, and nonvascular risk factors. Univariate analysis was performed using the chi-square test and a multivariate survey logistic regression analysis was performed to identify the prevalence of the risk factors and evaluate the odds of prevalence of risk factors amongst migraine patients compared to nonmigraine patients, respectively. Results: On weighted analysis, after removing missing data of age, gender and race, from years 2013 to 2014, of the total 983,065 (1.74%) migraine patients were identified. We found that younger (median age 48-years vs. 60-years), female (82.1% vs. 58.5%; p<0.0001), white population (76.8% vs. 70.5%; p<0.0001), and privately insured (41.1% vs. 27.4%; p<0.0001) patients were more likely to have migraine than others. Cerebral atherosclerosis, diabetes mellitus, ischemic heart disease, atrial fibrillation, and alcohol abuse were not significantly associated with migraine. Migraineurs had higher odds of having hypertension [odds ratio (OR):
Migraine: An emerging cardiovascular risk factor
2010
Conventional cardiovascular risk factors account for a significant proportion of cardiovascular diseases. The identification of novel and unconventional risk factors may provide strong advances in cardiovascular disease prevention, especially in young patients where these risk factors are less common. Robust evidence exists to support that migraine may be considered an emerging cardiovascular risk factor. Patients who experience migraine compared with non-migraineurs have an increased risk of developing ischaemic stroke. The evidence of such association is more pronounced for migraine with aura than for migraine without aura, and the risk of stroke is higher in young migrainous women but is also present in older women and in men. Moreover, women who experience migraine with aura compared with non-migrainous women have an increased risk of myocardial infarction, coronary revascularization, angina and death due to ischaemic cardiovascular disease. Men who experience migraine also have an increased risk of cardiovascular disease compared with non-migrainous men; however, in this case, the increase is driven mainly by myocardial infarction and not by ischaemic stroke. The mechanisms underlying the association between migraine and cardiovascular disease have not yet been clarified and several possibilities exist. The most probable hypothesis is that, at the basis of this association between migraine and cardiovascular disease, there is an endothelial dysfunction that may be responsible for both migraine and cardiovascular disease; despite there being several other hypotheses for this association, this particular hypothesis should not be overlooked. In the presence of other associated vascular risk factors, the risk of cardiovascular disease is further increased in migraineurs. For patients who experience migraine with aura, we recommend heightened vigilance and active control of cardiovascular risk factors. Further studies should investigate whether different preventive medications for migraine attacks might modify the cardiovascular risk in those who experience migraine. Cardiology and Clinical Practice 2010; 2 (1): 53-65 (ISSN: 2036-5802).
Cardiovascular disease risk in women with migraine
The Journal of Headache and Pain, 2013
Background: Studies suggest a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting. The aim of this study was to investigate traditional and newly recognized risk factors as well as other surrogate markers of cardiovascular risk in obese and normal weight women with migraine. Methods: Fifty-nine adult female probands participated in this case-control study. The sample was divided into normal weight and obese migraineurs and age-and body mass index-matched control groups. The following cardiovascular risk factors were analyzed: serum levels of lipids, fasting glucose, and insulin; insulin resistance; blood pressure; smoking (categorized as current, past or never); Framingham 10-year risk of general cardiovascular disease score; C-reactive protein; family history of cardiovascular disease; physical activity; sleep disturbances; depression; and bioelectrical impedance phase angle. The means of continuous variables were compared using Student's t-test for independent samples or the Mann-Whitney U-test (for 2 groups) and ANOVA or the Kruskal-Wallis test (for 4 groups) depending on the distribution of data. Results: All migraineurs were sedentary irrespective of nutritional status. Migraineurs had higher depression scores and shorter sleep duration, and obese migraineurs, in particular, had worse sleep quality scores. Insulin resistance and insulinaemia were associated with obesity, and obese migraineurs had lower HDL-c than normal weight controls and migraineurs. Also, the Framingham risk score was higher in obese migraineurs. Conclusion: These findings suggest that female migraineurs experience marked inactivity, depression, and some sleep disturbance, that higher insulin resistance and insulinaemia are related to obesity, and that obesity and migraine probably exert overlapping effects on HDL-c levels and Framingham 10-year cardiovascular risk.
Women with Migraine Having High Risk of Hypertension, Heart Disease and Stroke : A Quick Survey
Biomedical informatics is a field which mainly concentrates on the effective usage of medical data often provided by the use of technology and people to improve individual health. Currently headache is a significant trouble among human with regard to several causes. Tension, stress, Obesity and medication overuse are the main reasons for the occurrence of headache. The objective of this study is to conduct a systematic review of the effects of biomedical informatics applications with related to headaches. A data frame with 4152 observations on 133 subjects for 9 variables is taken for the study and from this a subset of data on migraine treatments collected by Tammy Kostecki-Dillon consist of headache entries kept in a treatment program. Patients entered the program at different times over a period of about 3 years. It is observed that women are having the high risk of occurrence migraines. This leads to higher degree of occurrence of hypertension and cardiovascular disorder in women than in men.
Prevalent migraine as a predictor of incident hypertension
2022
Migraine has been associated with several diseases. This population-based prospective Finnish postal survey Health and Social Support Study explored whether self-reported migraine predicted incident hypertension independently in a working-age population by utilising two data sources: the baseline survey from the year 1998 in combination with the follow-up survey data from the years 2003 and 2012 with linkage to the national Social Insurance Institution registry data of the special reimbursement medication for hypertension from 1999 to 2013. The survey follow-up reached until the second follow-up in the year 2012. The register follow-up also included the year 2013. The present population-based prospective cohort study, utilising two different data sources, included 8593 respondents (22.7% response rate) who participated in 1998, 2003, and 2012 but who did not report hypertension at the baseline in 1998, and whose responses could be linked with the Social Insurance Institution registr...
Migraines, Angiographic Coronary Artery Disease and Cardiovascular Outcomes in Women
The American Journal of Medicine, 2006
There are conflicting data regarding the association between migraines and cardiovascular events. We evaluated the relationship between migraine headaches, angiographic coronary artery disease, and cardiovascular events in women. SUBJECTS AND METHODS: The Women's Ischemia Syndrome Evaluation (WISE) study is a National Heart, Lung and Blood Institute (NHLBI)-sponsored prospective, multicenter study aiming to improve ischemia evaluation in women. A total of 944 women presenting with chest pain or symptoms suggestive of myocardial ischemia were enrolled and underwent complete demographic, medical, and psychosocial history, physical examination, and coronary angiography testing. A smaller subset of 905 women, representing a mean age of 58 years, answered questions regarding a history of migraines. We prospectively followed 873 women for 4.4 years for cardiovascular events and all-cause mortality. RESULTS: Women reporting a history of migraines (n ϭ 220) had lower angiographic coronary severity scores, and less severe (Ն 70% luminal stenosis) angiographic coronary artery disease compared to women without a history of migraines (n ϭ 685). These differences remained statistically significant after adjustment for age and other important cardiac risk factors. On prospective follow-up of a median of 4.4 years, women with a history of migraines were not more likely to have a cardiovascular event (hazard ratio [HR] 1.2; 95% confidence interal [CI], 0.93-1.58) and migraines did not predict all-cause mortality (HR 0.96; 95% CI, 0.49-1.99). CONCLUSION: Among women undergoing coronary angiography for suspected ischemia, those reporting migraines had less severe angiographic coronary artery disease. We could not support an association between migraines and cardiovascular events or death. Further research studying the common pathophysiology underlying migraines and cardiovascular disease is warranted.