An overview of Osmotic Drug Delivery System: An update review (original) (raw)

A Review on Osmotically Controlled Oral Drug Delivery Systems

2012

In the pharmaceutical research and development the novel drug delivery system (NDDS) plays remarkable performance. A milestone in oral NDDS is innovative and highly versatile drug delivery system. ODDS use the principle of osmotic pressure, as an energy source, for the delivery of drugs. Oral osmotic drug delivery systems with their versatile and their highly predictable drug release rates offer various biomedical advantages. Osmosis is one type of aristocrat phenomenon that seizes the attention for its exploitation in zero-order drug delivery systems. The drug delivered from these systems is not reliable of pH and the physiological conditions. Optimizing semipermeable membrane and the osmotic agents can modulate drug release from the system. In this article, a detailed description of various oral osmotically driven systems along with their formulation aspects, therapeutic applications and evaluation techniques are described.

A Comprehensive Review On Osmotically Controlled Oral Drug Delivery System

2020

Oral route is one of the most extensively used routes for drug administration for several advantages. In conventional oral drug delivery system, the release rate of drug cannot be controlled and effective concentration at the target site achieved is low. Bioavailability of drugs from the oral drug delivery may vary significantly, depending on factors such as physicochemical properties of the drug, presence of excipients, various physiological factors such as the presence or absence of food, pH of GIT, GI motility. OROS is an advanced drug delivery system that uses osmotic pressure as a driving force to deliver drug in a controlled manner for a longer period of time. In this review article, historical aspects related to osmotic pump, various types of osmotically controlled pumps like EOP, PPOS, CPOP, etc. have been studied. The basic components which are required for developing an oral osmotically controlled release formulations and factors affecting on release characteristics drug f...

An Overview on Osmotic Controlled Drug Delivery System

This paper reviews constructed drug delivery systems applying osmotic principles for controlled drug release from the formulation. Osmotic devices which are tablets coated with walls of controlled porosity are the most promising strategy based systems for controlled drug delivery. In contrast to common tablets, these pumps provide constant (zero order) drug release rate. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i.e. semipermeable membrane and drug releases in a controlled manner over an extended period of time. The main clinical benefits of oral osmotic drug delivery system are their ability to improve treatment tolerability and patient compliance. These advantages are mainly driven by the capacity to deliver drugs in a sustained manner, independent of the drug chemical properties, of the patient’s physiological factors or following food intake. This review brings out the theoretical concept of drug delivery, history, advantages and disadvantages of the delivery systems, types of oral osmotic drug delivery systems, factors affecting the drug delivery system and marketed products.

Advances in osmotic drug delivery system

2015

Osmotic drug delivery system (ODDS) utilizes the basic principle of osmotic pressure for controlled release of drugs. It provides the release of drugs in controlled manner to maintain drug concentration within therapeutic window and minimizing toxic effects. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH etc. That is why it can be utilized for systemic as well as targeted delivery of drugs. The drug release from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. The present study explains about an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.

Osmotic Controlled Drug Delivery Systems: An Overview

Osmotic controlled drug delivery systems utilize the principles of osmotic pressure for the controlled delivery of active agent. The delivery rate of zero-order is achievable with these systems. The release rate from these systems is highly predictable and can be programmed by modulating the release control parameters. The drug release from these systems is independent of gastric pH and hydrodynamic conditions. A high degree of in vivo-in vitro correlation (IVIVC) is obtained with osmotically controlled drug delivery systems. In this review various types of osmotic systems, basic components, patent literature and commercially marketed osmotic drug delivery systems are discussed.

Oral osmotically-drug driven systems: an overview

2020

Oral osmotically-driven systems has the capability to deliver medicine in an exceedingly sustained manner, freelance of the drug chemical properties, of the patient’s physiological factors or However, access to those technologies has been restricted by the producing challenges. During this critique, we have a tendency to shall offer a summary of the last 30years of OODS development, description the technologies, specific merchandise and their clinical use. General steering on technology choice is represented in light-weight of the recent advances within the field. Overall, oral osmotically-driven systems seem to be a promising technology for product lifecycle methods.

Osmotically Controlled Drug Delivery System with Associated Drugs

Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery. __________________________________________________________________________________________