Cobalt(III) Complexes with Thiosemicarbazones as Potential anti- Mycobacterium tuberculosis Agents (original) (raw)
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Facta universitatis - series: Physics, Chemistry and Technology, 2009
Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level.
International Journal of Molecular Sciences
Considering our previous findings on the remarkable activity exhibited by cobalt(III) with 2-acetylpyridine-N(4)-R-thiosemicarbazone (Hatc-R) compounds against Mycobacterium tuberculosis, the present study aimed to explored new structure features of the complexes of the type [Co(atc--R)2]Cl, where R = methyl (Me, 1) or phenyl (Ph, 2) (13C NMR, high-resolution mass spectrometry, LC–MS/MS, fragmentation study) together with its antibacterial and antiviral biological activities. The minimal inhibitory and minimal bactericidal concentrations (MIC and MBC) were determined, as well as the antiviral potential of the complexes on chikungunya virus (CHIKV) infection in vitro and cell viability. [Co(atc-Ph)2]Cl revealed promising MIC and MBC values which ranged from 0.39 to 0.78 µg/mL in two strains tested and presented high potential against CHIKV by reducing viral replication by up to 80%. The results showed that the biological activity is strongly influenced by the peripheral substituent g...
International Journal of Scientific Research in Science and Technology, 2023
An interesting series of cobalt(II) complexes of the new ligands: The antipyrinethiosemicarbazones 4[N-(benzalidene) amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(2-hydroxy-benzalidene)amino]antipyrinethiosemicarbazone (2b), and 4[N-(2-hydroxy-1-naphthalidene)amino]antipyrinethiosemicarbazone (2c) The complexes were discovered to have the typical stoichiometry [CoX2(H2O)(L)] and [Co(L)2](ClO4)2, where X = Cl, NO3, NCS, or CH3COO, and L =2a, 2b, or 2c. Elemental analyses, molar conductivity measurements, molecular weight estimations, magnetic moments at room temperature, infrared, and electronic spectra were used to describe the complexes. The behaviour of each and every thiosemicarbazone is that of neutral tridentate (N, N, S) donor ligands. The perchlorate complexes are 1:2 electrolytes, but the chloro, nitrato, thiocyanato, and acetate complexes are essentially non-electrolytes, according to the conductivity measurements in PhNO2 solution. Studies on thermodynamic behavior were conducted for a few typical complexes, and a decomposition process was suggested. The cobalt(II) complexes of the ligands and their antibacterial and antifungal activities have also been studied, and it has been found that the complexes are more effective bactericides than the ligands.
1995
Five new complexes of cobalt(II) have been synthesised by the interaction of fluphenazine (FPH) with cobalt(II) chloride, bromide, perchlorate, acetate or sulphate. The complexes which have been found to possess a stoichiometric composition of [Co(C22H26F3N3OS)(H2O)(2)X(2)] have been characterised for their purity with the help of elemental studies, conductivity and magnetic measurements. An octahedral structure has been proposed based on thermal, electronic and IR spectral data. The new complexes-have been tested in vitro for their antimicrobial activity against Alternaria alternata, Aspergillus flavus, Escherichia coli and Staphylococcus aureus. The antibacterial activity of the cobalt(II) complexes against E. coli and S. aureus increases in the order: sulphate > chloride > perchlorate.
Synthesis and Study of Cobalt Complexes
Journal of emerging technologies and innovative research, 2020
The origin of the name Cobalt is thought to stem from the German kabold for "evil spirits or goblins", who were superstitiously though to cause trouble for mines, since the cobalt minerals continued arsenic that injured their health and the cobalt ores did not yeild metals when treated using the normal methods. Metal ion complexes are playing an increasing role in the development of antimicrobials. In this research paper we study the antimicrobial properties of cobalt coordination complexes in oxidation state 3+. All complexes are found active when screen for their antimicrobial activity In UV-Vis spectrophotometeric study it is found that the, Hexamine cobalt (III) chloride absorbs at 240nm, Hexanitro cobaltate (III) absorbs at 228nm and hexanitro Co(III) absorbs at 222nm. Thermogravimetric analysis of Co(III) complex of Hexamine cobalt (III) chloride show mass at 80°c to 100°c is due to water lattice weight losses upon decomposition point shows thermal stability. In sodi...
2014
Complexes of Co(II), Ni(II) and Fe(III) with ampicillin and amoxicillin as ligands have been synthesized in aqueous solution and characterized by physical, IR and electronic spectra. The elemental data obtained agreed with the general formula [M(A)(C)].3H2O, where A= amoxicillin, C= ampicillin and M= metal ion. The IR spectra shows that the ligands coordinated to the metal ions through v(C=O), v(COO) and v(N-H) respectively due to their structural similarities. Electronic spectral data further revealed the probable geometry of Co(II) and Fe(III) complexes to be octahedral, while that of Zn(II) complex is tetrahedral. All the complexes and the ligands were screened for their biological activity on some selected bacterial species which includes:- Staphylococcus aurous, Streptococcus pyogene, Bacillus subtilis, Escherichia coli, Salmonella shigela, Klebsiella pneumoniae and Pseudomonas aeuroginosa. The results of biological activity indicated that the Co(II) and Ni(II) complexes have i...
Synthesis, Characterization and Anti-Microbial Screening of Iron (II) and Cobalt (II) Complexes
Journal of Natural Sciences Research, 2014
Metal complexes of Iron and Cobalt were synthesized and characterized using IR and UV Visible spectroscopy. Their decomposition temperatures and solubility in different solvents were also investigated. Both complexes were found to be soluble in Methanol, Ethanol, Chloroform, Ether, ammonia, DMSO, ethyl acetate, benzene, nitrobenzene and distilled water but insoluble in n-hexane. The decomposition temperatures of the synthesized Iron and cobalt complexes were in the range of 276 0 C-262 0 C and 263 0 C-253 0 C respectively. The IR spectra observed in all the complexes for v(C-O) and (C-O) showed a band at 1590 cm-1-1700cm-1 and around 1200cm-1-1700cm-1 respectively ; (M-O) and (N-M) bands also ranged from 800cm-1-800cm-1 and 1000cm-1-7500cm-1 respectively. The Uv-Vis result for the complexes showed Iron complex to have peaks at 400nm and a shoulder at 290nm; Cobalt (II) complex at 360nm and a shoulder at 400nm. Both the synthesized complexes showed the highest antimicrobial activity against E. Coli and Aspergilus at their highest concentrations. The synthesized Iron complex however, had the best anti-microbial potential than the Cobalt complex and penicillin put together when used in the highest prepared concentration: 0.20cm for the iron complex, 0.40cm and 0.3cm for the cobalt complex and penicillin respectively against E-coli and the same trend was observed for aspergillus.
pjps.pk
A number of biologically active complexes of cobalt(II) and nickel(II) with pyrazinedicarboxaimido derived thienyl and furanyl compounds having the same metal ion but different anions such as sulphate, nitrate, oxalate and acetate have been synthesized and characterized on the basis of their physical, spectral and analytical data. In order to evaluate the role of anions on their antibacterial properties, these ligands and their synthesized metal complexes with various anions have been screened against bacterial species Escherichia coil Pseztdomonas aeruginosa and Staphylococcus aurezs. The title studies have proved a definitive role of anions in increasing the antibacterial properties.
Chemistry Central Journal
Four novel complexes [Co(H 2 O) 4 (sul) 2 ] 1, [Co(2-ampy) 2 (sul) 2 ] 2, [Co(H 2 O) 2 (1,10-phen) (sul) 2 ] 3 and [Co(2,9-dimephen) (sul) 2 ] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV-Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.