New Cd(II), Mn(II) and Ag(I) Schiff Base Complexes : Synthesis, Characterization, DNA Binding and Antimicrobial Activity (original) (raw)
Related papers
Arabian Journal of …, 2011
A novel Schiff base ligand has been prepared by the condensation between butanedione monoxime with 3,3 0 -diaminobenzidine. The ligand and metal complexes have been characterized by elemental analysis, UV, IR, 1 H NMR, conductivity measurements, EPR and magnetic studies. The molar conductance studies of Cu(II), Ni(II), Co(II) and Mn(II) complexes showed non-electrolyte in nature. The ligand acts as dibasic with two N 4 -tetradentate sites and can coordinate with two metal ions to form binuclear complexes. The spectroscopic data of metal complexes indicated that the metal ions are complexed with azomethine nitrogen and oxyimino nitrogen atoms. The binuclear metal complexes exhibit octahedral arrangements. DNA binding properties of copper(II) metal complex have been investigated by electronic absorption spectroscopy. Results suggest that the copper(II) complex bind to DNA via an intercalation binding mode. The nucleolytic cleavage activities of the ligand and their complexes were assayed on CT-DNA using gel electrophoresis in the presence and absence of H 2 O 2 . The ligand showed increased nuclease activity when administered as copper complex and copper(II) complex behave as efficient chemical nucleases with hydrogen peroxide activation. The anti-microbial activities and thermal studies have also been studied. In anti-microbial activity all complexes showed good anti-microbial activity higher than ligand against gram positive, gram negative bacteria and fungi.
Journal of Chemical Sciences, 2007
A new series of transition metal complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II), VO(IV), Hg(II) and Cd(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, 3-hydroxy-4-nitrobenzaldehyde and o-phenylenediamine. Structural features were obtained from their elemental analyses, magnetic susceptibility, molar conductance, mass, IR, UV-Vis, 1 H NMR and ESR spectral studies. The data show that these complexes have composition of ML type. The UV-Vis, magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion except VO(IV) complex which has square-pyramidal geometry. The redox behaviour of copper and vanadyl complexes was studied by cyclic voltammetry. Antimicrobial screening tests gave good results in the presence of metal ion in the ligand system. The nuclease activity of the above metal complexes shows that Cu, Ni and Co complexes cleave DNA through redox chemistry whereas other complexes are not effective.
Synthesized and hypothesized schiff base ligand and its metal(II) complexes DNA binding mode
Bulletin of the Chemical Society of Ethiopia
ABSTRACT. Metal complexes play an important role in agriculture, pharmacology, medicine, and industrial chemistry. Schiff base metal compounds are the fusion products of propene and aldehydes, require a metal surrounded by an ion or cluster of molecules to form. Metal complexes of Co(II), Ni(II), Cu(II), and Zn(II) have also been created. Elemental analysis is used to analyses the structure and related compounds of the produced Schiff base ligand. According to deoxyribose nucleic acid (DNA) binding tests, Schiff base metal(II) complexes attach to DNA in an intercalative form with weak covalent connections. The predicted DNA binding mode supports an increase in the complexes' binding activity in the presence of newly generated ligand. The cleavage activities of the DNA were recorded using gel-electrophoresis in the presence and absence of the complexes. The findings of the cleavage experiment show that all of the produced chelates can successfully cut DNA. KEY WORDS: Schiff bas...
The Schiff base 2-amino-N(2-(R)-2-amino-1-hydroxy-3-phenylpropylidene)amino) ethyl)-3-phenylpropanimidic was obtained by refluxed condensation of ethylenediamine with phenylalanine. The ligand was isolated by filtration, washed with water-ethanol mixture and characterized by FTIR, UV-visible spectroscopy, melting point determination and conductivity test. The compound was used to prepare the complexes of Mn(II), Co(II), Ni(II), Zn(II) and Cd(II). The metal-ligand ratio was determined using the Job's method of continuous variation. From the result of IR spectroscopy, the structure of the proposed ligand showed an absorption of 1558cm-1 due to azomethine which was shifted to higher frequency range of 1559-1624cm-1 upon complexation with metal ions that coordinated the ligand through both oxygen and nitrogen.
The meal complexes of Co(II), Ni(II), Cu(II), Cd(II) and Zn(II) derived from hydroxyl benzophenone and o-phenylenediamine have been synthesised and characterized by elemental analysis, 1 H NMR, FT-IR, UV-visible, Mass spectroscopy, molar conductometry, magnetic susceptibility and thermal analysis study. The FT-IR spectral study reveals that the ligand behaves as a dibasic tetradentate ligand with N 2 O 2 donor atoms sequence towards central metal ion. The physico-chemical study reveals octahedral geometry for the complexes. The results show the formation of 2:1(ligand: metal chloride) complexes with amine and screened for anti-inflammatory, antimicrobial, DNA binding properties.During the past two decades, considerable attention has been paid to the chemistry of metal complexes containing nitrogen and other donor 1. The tetradentate Schiff base complexes are well known to form stable complexes, where coordination takes place through the N 2 O 2 donor set 2-4. N, O-bidentate and N 2 O 2-tetradentate ligands (soft and hard donor) possess many, advantages such as facile approach, relative tolerance, readily adjusted ancillary ligands, and tunable steric and electronic coordination environments on the metal center 5. This may be attributed to their potential application in many fields such as oxidation catalysis 6 and electrochemistry 7. Transition metals are involved in many biological processes which are essential to life process. The metals can coordinate with O-or N-terminals from proteins in a variety of models and play a crucial role in the conformation and function of biological macromolecules 8, 9. This paper reports the synthesis, characterization, thermal and biological studies of metal(II) complexes derived from the reaction of hydroxyl benzophenone and o-phenylenediamine in alcohol. Experimental section:-Materials and Methods:-All the chemicals used in the preparation of Schiff base and its metal complexes were of AR grade. A Perkin-Elmer CHN analyzer (model 2400) was used for C, H and N analyses. The room temperature molar conductance was determined using a Century digital conductivity meter (model cc 601) with a dip type cell and a smooth platinum electrode. The electronic absorption spectra of the complexes were recorded as dilute solutions on a Shimadzu 160A/240A UV-visible spectrophotometer. The 1 H NMR spectra were recorded using Bruker DRX 400 spectrometer at 400 MHz with TMS as the internal standard. Mass spectra were obtained with a VG70-70H
The Pharma Innovation Journal, 2016
The new bidentate Schiff base ligand namely [(E)-N 1-(4-methoxy benzylidene) benzene-1, 2-diamine] was prepared from condensation of 4-Methoxy benzaldehyde with O-Phenylene diamine at 1:1 molar ratio in ethanol as a solvent in presence of drops of 48% HBr. The structure of ligand (L) was characterized by, FT-IR, U.V-Vis., 1 H-, 13 C-NMR spectrophotometer, melting point and elemental microanalysis C.H.N. Metal complexes of the ligand (L) in general molecular formula [M(L)3], where M= Mn(II), Co(II), Ni(II),Cu(II) and Hg(II); L=(C14H14N2O) in ratio (1:3)(Metal:Ligand) were synthesized and characterized by Atomic absorption, FT-IR, U.V-Vis. spectra, molar conductivity, chloride content, melting point and magnetic susceptibility from the above data the geometrical formula was octahedral for all complexes. And in vitro tests for antibacterial activity showed that most of the prepared compounds display activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeruginosa).
With the aim of exploring biological properties of coordination compounds, we report for the first time novel Cu(II), Ni(II), Co(II) and Mn(II) complexes with newly synthesized heterocyclic Schiff base ligands derived from 4-chloro phenylenediamine, furfuraldehydeand2, 2′ bipyridyl. These compoundswere characterized by a set of chemical and spectroscopic methods to study elemental analysis, electrical conductance, magnetic susceptibility and spectral techniques that include IR, UV–Visand EPR. Elemental analysis data are consistent with the proposed formula. IR spectra confirm the hexadentate nature and coordination of the Schiff base complex. The octahedral geometry ofcomplexesis suggested by UV–Vis spectra and magnetic moment data. Antibacterial activities of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus, Bacillus subtilis as Gram positive bacteria, Escherichia coli and Klebsilla pneumonia as Gram negative bacteria and the results were discussed. The results showed an effective antimicrobial activity of the metal ions after coordination with the ligands. The nucleolytic cleavage activities of the complexes were carried out using gel electrophoresis.
SYNTHESIS, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL ACTIVITY OF NOVEL SCHIFF BASE METAL COMPLEXES
Mononuclear Copper(II), Nickel(II) and Oxovanadium(IV) complexes of new tetradendate Schiff base ligand derived from the condensation of 5-Bromosalicylaldehyde, 4,5, dichloro o-phenylenediamine with pentane-2,4-dione have been synthesized and characterized by analytical, spectral and electrochemical methods. The complexes were found to have the general formula [M(L)]X (where M = (Cu(II), Ni(II), and VO(IV) X=ClO4-, (SO4) 2-L = mononucleating tetradendate ligand). The invitro antimicrobial activities of the synthesized compounds have been tested against the gram negative and gram positive bacteria. A comparative study of minimum inhibitory concentration (MIC) values of the Schiff base and its complexes indicate that the metal complexes exhibit higher antibacterial activity than the free ligand. © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 1521
TJPRC, 2013
Cu(II), Ni(II) and VO(II) complexes have been synthesized using 4,4'-Bis-[1-ethyl-2-(2-hydroxy-phenylimino)- propylideneamino]-biphenyl-3,3'-diol as a ligand derived from 3, 3′-dihydroxybenzidine, 2, 3- pentanedione and 2- aminophenol. All the metal complexes have been fully characterized with the help of analytical, conductivity, IR, electronic, magnetic, ESR and NMR studies. The Schiff bases are found to act as a tetradentate ligand using N2O2 donor set of atoms leading to a square-planar geometry for the Cu(II), Ni(II) and square pyramidal for VO(II) complexes. Their biological efficacy as antibacterial, antifungal, antioxidant, DNA cleavage and interaction with CTDNA was carried out, and showed remarkable activities in each area of research. The binding properties of metal complexes with DNA have been investigated by electronic absorption spectra and viscosity measurements showing that the complexes have the ability of interaction with DNA by intercalative mode. All the metal complexes cleave the pUC18DNA in presence of H2O2. The antibacterial activity of these compounds was studied in vitro by the disc diffusion assay against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis and two Gram-negative bacteria like Escherichia coli and Klebsilla pneumonia, where as the antifungal against Fusarium oxysporum and Aspergillus fumigates. Additionaly, the antioxidant activities of the complexes were also investigated through scavenging effect on DPPH, OH radicals, ABTS and reducing power activity.