Macrocyclic peptidomimetics with nanomolar antifungal and antimicrobial activity (original) (raw)

Abstract

ABSTRACT Enantiopure cyclic peptidomimetic antimicrobials compds. that contain S- cysteine ester units and at least one pyridine unit within the macrocyclic ring have been prepd. that show exceptional antifungal and antibacterial activity. These 17- or 18- membered macrocyclic compds. display MIC values as antifungal agents as low as 7.5 nm /mL and MIC values as antibacterial agents as low as 0.2 nm /mL. All the macrocyclic peptidomimetic compds. are isolated as cryst. solids in good yield

Girinath G. Pillai hasn't uploaded this paper.

Let Girinath know you want this paper to be uploaded.

Ask for this paper to be uploaded.