Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE) (original) (raw)

2009, Human Molecular Genetics

AI-generated Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with a significant genetic component, particularly influenced by variants in the ITGAM gene. This study evaluates associations between various SNPs in and around ITGAM using imputation-based analysis across multiple ethnic groups including European-Americans, Hispanic-Americans, Koreans, and Japanese. Results demonstrate a strong association of SNP rs1143679 with SLE, replicated in diverse cohorts, underscoring the relevance of ITGAM variations in SLE susceptibility.

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