Shear strain in the adventitial layer of the arterial wall facilitates development of vulnerable plaques (original) (raw)

Bioscience Hypotheses, 2009

Abstract

Myocardial infarction and stroke are two of the leading causes of death and primarily triggered by destabilization of atherosclerotic plaques. Fatty streaks are known to develop at sites in the arterial wall where shear stress is low. These fatty streaks can develop into more advanced plaques that are prone to rupture. Rupture leads to thrombus formation, which may subsequently result

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