Long-term corrosion performances and cytocompatibility of nitrided Ti and Ti-6Al-4V alloy in severe functional conditions (original) (raw)
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Materials Chemistry and Physics, 2019
Over the last decade, new titanium alloys are developed in different areas of implantology. The aim of this study was to characterize a new Ti-Al-Nb-Ta-Mo based alloy, with high potential for being used as a biomedical implant. The evaluation of Ti-6Al-2Nb-2Ta-1Mo was performed both in vitro (by monitoring its corrosion resistance in Hank's Balanced Salt Solution, HBSS) and in vivo (by evaluating the osseointegration following rabbit tibia implantation), by comparison with titanium and Ti-6Al-7Nb alloy. Electrochemical impedance spectroscopy (EIS) data showed high impedance values for all titanium samples after 1 week immersion times in HBSS at 37 o C. According to EIS analysis, the corrosion resistance of the Ti-6Al-2Nb-2Ta-1Mo alloy immersed in HBSS was higher compared to the standard cp-Ti or with the Ti-6Al-7Nb alloy. In addition, a higher degree of osseointegration was achieved by the Ti-6Al-2Nb-2Ta-1Mo alloy, thus probing that a higher resistance to electrochemical corrosion provided enhanced protection to the implant surface against biodegradation, thus positively affecting the qualitative and quantitative evolution of bone tissue repair.
In vitro biocompatibility and corrosion resistance of a new implant titanium base alloy
Journal of Materials Science: Materials in Medicine, 2010
One objective of this work was to study the corrosion resistance of the new implant Ti-10Zr-5Ta-5Nb alloy in physiological fluids of different pH values, simulating the extreme functional conditions. Another objective was in vitro biocompatibility evaluation of the new alloy using human fetal osteoblast cell line hFOB 1.19. Cytocompatibility was assessed by determination of possible material cytotoxic effects, cell morphology and cell adhesion. The thermo-mechanical processing of the new implant alloy consisted in plastic deformation (almost 90%) performed by hot rolling accompanied by an initial and final heat treatment. The new Ti-10Zr-5Ta-5Nb alloy presented self-passivation, with a large passive potential range and low passive current densities, namely, a very good anticorrosive resistance in Ringer solution of acid, neutral and alkaline pH values. Cell viability was not affected by the alloy substrate presence and a very good compatibility was noticed.
Effect of calcium-ion implantation on the corrosion resistance and biocompatibility of titanium
Biomaterials, 2001
This work presents data on the structure and corrosion resistance of titanium after calcium-ion implantation with a dose of 10Ca>/cm. The ion energy was 25 keV. Transmission electron microscopy was used to investigate the microstructure of the implanted layer. The chemical composition of the surface layer was examined by XPS and SIMS. The corrosion resistance was examined by electrochemical methods in a simulated body #uid (SBF) at a temperature of 373C. Biocompatibility tests in vitro were performed in a culture of human derived bone cells (HDBC) in direct contact with the materials tested. Both, the viability of the cells determined by an XTT assay and activity of the cells evaluated by alkaline phosphatase activity measurements in contact with implanted and non-implanted titanium samples were detected. The morphology of the cells spread on the surface of the materials examined was also observed. The results con"rmed the biocompatibility of both calcium-ion-implanted and non-implanted titanium under the conditions of the experiment. As shown by TEM results, the surface layer formed during calcium-ion implantation was amorphous. The results of electrochemical examinations indicate that calcium-ion implantation increases the corrosion resistance, but only under stationary conditions; during anodic polarization the calcium-ion-implanted samples undergo pitting corrosion. The breakdown potential is high (2.7}3 V).
Materials and Corrosion, 2007
In vitro osteoblasts/Ti-6AI-7Nb bioalloy interactions were characterized in this paper. Also, the electrochemical properties of the passive films on titanium and its Ti-6Al-7Nb bioalloy in Ringer 2 and 3 solutions were determined as an aspect of their biocompatibility. Human osteoblast proliferation and viability are very good. "Cell effort" to adhere on metallic support is visualized by some morphologic changes of the osteoblasts. Cytotoxicity effects of Ti-6AI-7Nb alloy appeared after 48 culture hours and decreased in time, demonstrating a very good biocompatibility. In Ringer 2 solution of different pH values (2.5; 5; 6.7 and 9), titanium and Ti-6Al-7Nb alloy presented self-passivation, very large passive potential range, very low passive current densities, confirming a compact, protective, stable layer. The very low corrosion rates and ion release values prove a near imperceptible toxicity. In Ringer 3 solution, open circuit potentials of titanium and its Ti-6AI-7Nb alloy tend to electropositive values, attesting a process of passivity increase by thickening.
Effect of sodium-ion implantation on the corrosion resistance and bioactivity of titanium
Vacuum, 2005
The corrosion resistance and bioactivity of titanium after sodium-ion implantation were examined. Polished samples were implanted with a dose of 10 17 Na + /cm 2 at a beam energy of 25 keV. The chemical composition of the surface layer formed during the implantation was determined by X-ray photoelectron spectroscopy (XPS) and secondary ion mass spectrometry (SIMS). The bioactivity of the samples was evaluated by soaking them in a simulated body fluid (SBF) at 37 1C for 168 and 720 h. The corrosion resistance in SBF at 37 1C was determined by electrochemical methods after exposure in SBF for various times. The results obtained indicate that sodium-ion implantation improve the corrosion resistance after short-term exposures. During an exposure in SBF, calcium phosphates precipitate on the sample surface but they do not form a continuous layer. r
Corrosion and cell adhesion behavior of TiN-coated and ion-nitrided titanium for dental applications
Applied Surface Science, 2005
This study investigated the corrosion resistance and cell adhesion behavior of titanium nitride (TiN)-coated and ion-nitrided Ti substrates for dental applications. The TiN-coated specimen surface layer contained a TiN/Ti structure, while the ion-nitrided specimen contained a Ti 2 N/TiN/Ti structure. The polarization curves in artificial saliva showed that the corrosion rate and passive current for the specimens ranked as: untreated Ti > ion-nitrided Ti > TiN-coated Ti. The polarization resistance obtained from the electrochemical impedance spectroscopy ranked as: TiN-coated Ti > ion-nitrided Ti > untreated Ti. After 24 h osteoblast-like U-2 OS cell incubation on the specimens, the attached cell number occurred in the order: TiN-coated Ti > ion-nitrided Ti > untreated Ti. The TiN-coating and ion-nitriding treatments can improve the corrosion resistance and cell adhesion behavior of Ti. # 2004 Published by Elsevier B.V.
Thin Solid Films, 2013
The biocompatibility of an implant material is determined by its surface characteristics. This study investigated the application of an electrochemical anodization surface treatment to improve both the corrosion resistance and biocompatibility of Ti-6Al-7Nb alloy for implant applications. The electrochemical anodization treatment produced an Al-free oxide layer with nanoscale porosity on the Ti-6Al-7Nb alloy surface. The surface topography and microstructure of Ti-6Al-7Nb alloy were analyzed. The corrosion resistance was investigated using potentiodynamic polarization curve measurements in simulated blood plasma (SBP). The adhesion and proliferation of human bone marrow mesenchymal stem cells to test specimens were evaluated using various biological analysis techniques. The results showed that the presence of a nanoporous oxide layer on the anodized Ti-6Al-7Nb alloy increased the corrosion resistance (i.e., increased the corrosion potential and decreased both the corrosion rate and the passive current) in SBP compared with the untreated Ti-6Al-7Nb alloy. Changes in the nanotopography also improved the cell adhesion and proliferation on the anodized Ti-6Al-7Nb alloy. We conclude that a fast and simple electrochemical anodization surface treatment improves the corrosion resistance and biocompatibility of Ti-6Al-7Nb alloy for biomedical implant applications.
The Journal of the Indian Prosthodontic Society, 2017
Purpose: The aim of this study was to investigate the cytotoxicity in human gingival fibroblast by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and corrosion behavior by potentiodynamic polarization technique of commercially pure titanium (Ti 12) and its alloy Ti-6Al-4V (Ti 31). Materials and Methods: In the present in vitro study, cytotoxicity of Ti 12 and Ti 31 in human gingival fibroblast by MTT assay and the corrosion behavior by potentiodynamic polarization technique in aqueous solutions of 0.1 N NaCl, 0.1 N KCl, and artificial saliva with and without NaF were studied. Results: The independent t-test within materials and paired t-test with time interval showed higher cell viability for Ti 12 compared to Ti 31. Over a period, cell viability found to stabilize in both Ti 12 and Ti 31. The effects of ions of Ti and alloying elements aluminum and vanadium on the cell viability were found with incubation period of cells on samples to 72 h. The electrochem...
Corrosion behaviors of Ti-13Nb-13Zr and Ti-6Al-4V alloys for biomaterials application
Corrosion Science and Technology (Korea), Vol. 9, 2010, 12-15 (https://inis.iaea.org/search/search.aspx?orig\_q=RN:43125276)
Ti-13Nb-13Zr (TNZ) alloy has attracted considerable research attention in the last decade as a suitable substitute for the commercially used Ti-6Al-4V (TAV) alloy for orthopedic and dental implant applications. Hence, in the present work, a comparative evaluation has been performed on the electrochemical corrosion behavior of TNZ and TAV alloys in 0.9 wt.% NaCl solution. The result of the study showed that both the alloys had similar electrochemical behavior. The corrosion resistance of TAV alloy is found to be marginally superior to that of TNZ alloy
Properties of the surface layers on titanium alloy and their biocompatibility in in vitro tests
Journal of Materials Processing Technology, 1999
Recently, it has been suggested that the future designs of implants and endoprothesis should be focused on the use of a new generation of biocompatible, corrosion and wear resistant materials or materials currently used but modi®ed by surface engineering processes. The aim of the study was to investigate the features of titanium oxide and titanium nitride layers produced on titanium alloy by plasma nitriding and oxidizing under glow discharge conditions and their biocompatibility in in vitro tests. The plasma nitriding and oxidizing techniques essentially improved the properties of titanium alloys. Their microstructure and the results of hardness, wear and corrosion resistance tests are presented. In the investigations of the cellular responses of human ®broblast cells to these layers, three aspects were considered: the number of growing cells, their morphological features and their biological corrosion resistance. Nitriding and oxidizing under glow discharge conditions have provided new possibilities of producing non-toxic, human ®broblast-compatible surface layers on parts made of titanium alloys with sophisticated shapes. Uniform surface layers having a controlled microstructure and phase composition can contribute to the opening of a wider application range of titanium alloys as biomaterials.