Activation of the cyclic nucleotide phosphodiesterase from rat heart cytosol by phospholipase C (original) (raw)

Phospholipase C from Clostridium perfringens significantly enhances the cyclic nucleotide phosphodiesterase activity in rat heart cytosol, specifically affecting cyclic AMP and cyclic GMP phosphodiesterases in varying contexts, depending on the presence of calcium ions and EGTA. The findings suggest that this activation is predominantly related to alterations in phospholipid metabolism, particularly involving phosphatidic acid, and highlights the need for additional studies to explore these mechanisms further.