Involvement of Distinct Cellular Compartments in the Abnormal Lymphoid Organogenesis in Lymphotoxin-α-Deficient Mice and Alymphoplasia (aly) Mice Defined by the Chimeric Analysis (original) (raw)

Lymphocytes migrate to secondary lymphoid organs, which are vital for initiating immune responses against antigens. This paper investigates the mechanisms and cellular compartments involved in lymphoid organogenesis, specifically in Lymphotoxin-α-deficient and alymphoplasia mice, using chimeric analysis. Key findings reveal distinct roles for Lymphotoxin-α in the organogenesis of lymph nodes and Peyer's patches, highlighting the complex interactions between various signaling pathways that regulate lymphoid tissue development.