The determinants of periorbital skin ageing in participants of a melanoma case-control study in the U.K (original) (raw)

2011, British Journal of Dermatology

AI-generated Abstract

Skin ageing is influenced by various factors, notably sun exposure, which may encourage sun protection. This study evaluates skin ageing in melanoma study participants, focusing on periorbital skin as a potential objective marker for sun exposure. Employing proportional odds regression, the research examines clinical indicators such as wrinkles, vascularity, and pigmentation in relation to factors including age, sex, MC1R gene variants, sun exposure, smoking, and BMI. Findings reveal that while wrinkling is a poor biomarker for sun exposure, vascularity and blotchy pigmentation are more effective, particularly among dark-skinned individuals. Key associations include male sex, sun exposure, smoking, obesity, and MC1R variants, with sunscreen use offering some protective benefits.